Exploring how a hazardous fungal pathogen 'tastes' its surroundings within a wheat plant to coordinate virulence could be the key to developing new control strategies, scientists believe.
Biotechnology
Apr 24, 2019
0
36
G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...
Biochemistry
Dec 4, 2018
0
71
Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical ...
Cell & Microbiology
Nov 26, 2018
0
35
In November 2017, a Titan Krios cryo-electron microscope (cryo-EM) was inaugurated at the ESRF, the European Synchrotron, France. Data collected on this cryo-EM features in a Nature publication describing the activation cycle ...
Biochemistry
Oct 31, 2018
0
22
The complex architecture of bone is challenging to recreate in the lab. Therefore, advances in bone tissue engineering (BTE) aim to build patient-specific grafts that assist bone repair and trigger specific cell-signaling ...
Hormones and other neurotransmitters, but also drugs, act upon receptors. "Their active substances bind to the receptors and modify the three-dimensional receptor arrangement regulating the downstream signal pathways," says ...
Biochemistry
Sep 6, 2018
0
5
About 30 percent of the proteins encoded by the human genome are membrane proteins—proteins that span the cell membrane so they can facilitate communication between cells and their environment. These molecules are critical ...
Biochemistry
Aug 28, 2018
0
110
For the first time, scientists have visualized the interaction between two critical components of the body's vast cellular communication network, a discovery that could lead to more effective medications with fewer side effects ...
Biochemistry
Jun 13, 2018
0
24
Researchers hope to design a new generation of drugs against an array of deadly diseases. The task, however, is costly, arduous and often ineffective. One of the key challenges is understanding a particular class of proteins ...
Biochemistry
Apr 5, 2017
0
109
