Proteins are the workhorses of our cells, carrying out essential tasks to keep our cells – and our bodies – functioning properly. But proteins can only do their jobs if they fold into the right shape.
Cell & Microbiology
Nov 28, 2018
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Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest ...
Cell & Microbiology
Mar 4, 2014
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Scientists from the group of Professor Dr. Thorsten Hoppe at the Cologne Cluster of Excellence for Aging Research CECAD have found that in the nematode C. elegans, the perception of changes in ambient temperature via a defined ...
Cell & Microbiology
Oct 7, 2022
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Proteins are huge molecules containing hundreds to thousands of atoms that adopt a unique three dimensional structure, placing chemical groups in just the right place to catalyze reactions or build cellular structures. How ...
Biochemistry
Oct 19, 2015
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Very small exhaled droplets, so-called aerosol particles, play an important role in the airborne transmission of pathogens such as the coronavirus. Researchers in the field of fluid mechanics used a model to investigate how ...
General Physics
Dec 8, 2022
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In adhering to body cells, many bacteria cause disease. Antibiotics are the usual means for treating infection, but decades of use have led to increasing bacterial resistance. Therefore, scientists are looking at other strategies.
Cell & Microbiology
Sep 19, 2016
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The evolutionary history of proteins shows that protein folding is an important factor. Especially the speed of protein folding plays a key role. This was the result of a computer analysis carried out by researchers at the ...
Cell & Microbiology
Jan 31, 2013
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Temperature and dissolved oxygen (DO) can affect a series of physiological and biochemical responses and drive the expression of regulatory genes. When water temperature increases, the solubility of oxygen decreases, leading ...
Plants & Animals
Jan 21, 2022
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Molecular dynamics simulations (MD) have become a ubiquitous tool in modern life sciences. In these simulations, the interactions between atoms and molecules and their resulting spatial movements are iteratively calculated ...
Cell & Microbiology
Jun 10, 2020
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In biophysics, the kinetic states of molecules play a determining role in the metabolic and physiological processes in which they take part. Now, a paper published in the journal Proceedings of the National Academy of Sciences ...
Biotechnology
Mar 23, 2022
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