When it comes to drug development, membrane proteins play a crucial role, with about 50% of drugs targeting these molecules. Understanding the function of these membrane proteins, which connect to the membranes of cells, ...
Cell & Microbiology
Feb 8, 2024
0
39
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal ...
Cell & Microbiology
Jan 2, 2024
0
66
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require ...
Biochemistry
Dec 28, 2023
0
203
Historically, one of the primary ways organic chemists have explored and created compounds is by constructing a carbon skeleton and making modifications to its structure. But instead of building a carbon skeleton from scratch ...
Biochemistry
Dec 20, 2023
0
45
A new study in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University ...
Biotechnology
Dec 18, 2023
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85
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
0
20
Biomedical engineers at Duke University have developed an AI platform that autonomously compares molecules and learns from their variations to anticipate property differences critical to discovering new pharmaceuticals. The ...
Biochemistry
Dec 4, 2023
0
107
A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like ...
Biochemistry
Nov 8, 2023
0
45
Snakebites cause around 100,000 deaths worldwide every year. Researchers at the Technical University of Munich (TUM) have investigated how the toxin emerged between 50 and 120 million years ago through the modification of ...
Evolution
Oct 9, 2023
0
131
Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings, which were reported in the ...
Molecular & Computational biology
Sep 7, 2023
0
81
