Over the past two decades, microfluidic devices, which use technology to produce micrometer-sized droplets, have become crucial to various applications. These span chemical reactions, biomolecular analysis, soft-matter chemistry, ...
Biotechnology
Feb 6, 2024
0
0
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal ...
Cell & Microbiology
Jan 2, 2024
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66
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require ...
Biochemistry
Dec 28, 2023
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203
Historically, one of the primary ways organic chemists have explored and created compounds is by constructing a carbon skeleton and making modifications to its structure. But instead of building a carbon skeleton from scratch ...
Biochemistry
Dec 20, 2023
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45
A new study in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University ...
Biotechnology
Dec 18, 2023
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85
The field of epigenetics focuses on alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications ...
Molecular & Computational biology
Dec 6, 2023
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2
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
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20
Biomedical engineers at Duke University have developed an AI platform that autonomously compares molecules and learns from their variations to anticipate property differences critical to discovering new pharmaceuticals. The ...
Biochemistry
Dec 4, 2023
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107
Investigators led by Neil Kelleher, Ph.D., professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, have developed an automated technique for imaging and identifying proteoforms ...
Biotechnology
Nov 10, 2023
1
48
A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like ...
Biochemistry
Nov 8, 2023
0
45
