A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.
Cell & Microbiology
Oct 24, 2022
0
23
Joining forces with the Ciaudo (IMHS) and Hall (IPW, D-CHAB) labs, the Allain group (IBC) gained structural insights into the unusual mode of RNA recognition by the Dead End protein complemented by biochemical and cellular ...
Cell & Microbiology
Oct 11, 2022
0
11
Thanks to new RNA vaccines, we humans have been able to protect ourselves incredibly quickly from new viruses like SARS-CoV-2, the virus that causes COVID-19. These vaccines insert a piece of ephemeral genetic material into ...
Cell & Microbiology
Oct 5, 2022
0
46
DNA double-strand breaks are one of the biggest threats to the genome and a driving force of carcinogenesis. Cellular repair mechanisms such as homologous recombination are essential for the maintenance of genome stability ...
Cell & Microbiology
Aug 24, 2022
0
10
The molecules of life, DNA, replicate with astounding precision, yet this process is not immune to mistakes and can lead to mutations. Using sophisticated computer modeling, a team of physicists and chemists at the University ...
General Physics
May 5, 2022
3
3338
Challenging the dogma of what scientists thought they understood about DNA viruses, a team of researchers led by Children's Hospital of Philadelphia (CHOP) has shown that adenovirus uses its own efficient RNA splicing mechanisms ...
Molecular & Computational biology
Oct 21, 2021
0
68
DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. ...
Cell & Microbiology
Jul 9, 2021
0
221
Telomeres are large nucleoproteins structures that cap the ends of chromosomes in eukaryotic cells. When a cell divides, a small portion of the telomere is lost due to the inherently incomplete process of genome replication. ...
Biotechnology
Apr 22, 2021
0
197
From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this ...
Molecular & Computational biology
Apr 15, 2021
0
150
When large forces act on a heavy beam, for example, in bridge construction, the beam will be slightly deformed. Calculating the relationship between forces, internal stresses and deformations is one of the standard tasks ...
Molecular & Computational biology
Aug 5, 2020
0
80
