Quantum mechanics could explain why DNA can spontaneously mutate

3D-model of DNA. Credit: Michael Ströck/Wikimedia/ GNU Free Documentation License

The molecules of life, DNA, replicate with astounding precision, yet this process is not immune to mistakes and can lead to mutations. Using sophisticated computer modeling, a team of physicists and chemists at the University of Surrey have shown that such errors in copying can arise due to the strange rules of the quantum world.

The two strands of the famous DNA double helix are linked together by called protons—the nuclei of atoms of hydrogen—which provide the glue that bonds molecules called bases together. These so-called are like the rungs of a twisted ladder that makes up the structure discovered in 1952 by James Watson and Francis Crick based on the work of Rosalind Franklin and Maurice Wilkins.

Normally, these DNA bases (called A, C, T and G) follow strict rules on how they bond together: A always bonds to T and C always to G. This strict pairing is determined by the molecules' shape, fitting them together like pieces in a jigsaw, but if the nature of the hydrogen bonds changes slightly, this can cause the pairing rule to break down, leading to the wrong bases being linked and hence a mutation. Although predicted by Crick and Watson, it is only now that sophisticated computational modeling has been able to quantify the process accurately.

The team, part of Surrey's research program in the exciting new field of quantum biology, have shown that this modification in the bonds between the DNA strands is far more prevalent than has hitherto been thought. The protons can easily jump from their usual site on one side of an energy barrier to land on the other side. If this happens just before the two strands are unzipped in the first step of the copying process, then the error can pass through the replication machinery in the cell, leading to what is called a DNA mismatch and, potentially, a mutation.

In a paper published this week in the journal Communications Physics, the Surrey team based in the Leverhulme Quantum Biology Doctoral Training Center used an approach called open quantum systems to determine the physical mechanisms that might cause the protons to jump across between the DNA strands. But, most intriguingly, it is thanks to a well-known yet almost magical quantum mechanism called tunneling—akin to a phantom passing through a solid wall—that they manage to get across.

It had previously been thought that such quantum behavior could not occur inside a living cell's warm, wet and complex environment. However, the Austrian physicist Erwin Schrödinger had suggested in his 1944 book "What is Life?" that quantum mechanics can play a role in living systems since they behave rather differently from inanimate matter. This latest work seems to confirm Schrödinger's theory.

In their study, the authors determine that the local cellular environment causes the protons, which behave like spread out waves, to be thermally activated and encouraged through the energy barrier. In fact, the protons are found to be continuously and very rapidly tunneling back and forth between the two strands. Then, when the DNA is cleaved into its separate strands, some of the protons are caught on the wrong side, leading to an error.

Dr. Louie Slocombe, who performed these calculations during his Ph.D., explains that: "The protons in the DNA can tunnel along the hydrogen bonds in DNA and modify the bases which encode the genetic information. The modified bases are called "tautomers" and can survive the DNA cleavage and replication processes, causing "transcription errors" or mutations."

Dr. Slocombe's work at the Surrey's Leverhulme Quantum Biology Doctoral Training Center was supervised by Prof Jim Al-Khalili (Physics, Surrey) and Dr. Marco Sacchi (Chemistry, Surrey).

Prof Al-Khalili comments: "Watson and Crick speculated about the existence and importance of quantum mechanical effects in DNA well over 50 years ago, however, the mechanism has been largely overlooked."

Dr. Sacchi continues: "Biologists would typically expect tunneling to play a significant role only at low temperatures and in relatively simple systems. Therefore, they tended to discount quantum effects in DNA. With our study, we believe we have proved that these assumptions do not hold."

More information: An open quantum systems approach to proton tunnelling in DNA, Communications Physics (2022). DOI: 10.1038/s42005-022-00881-8 , www.nature.com/articles/s42005-022-00881-8

Journal information: Communications Physics

Citation: Quantum mechanics could explain why DNA can spontaneously mutate (2022, May 5) retrieved 25 July 2024 from https://phys.org/news/2022-05-quantum-mechanics-dna-spontaneously-mutate.html
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