Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks—damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling ...
Biochemistry
Jul 27, 2023
0
61
Breaks in DNA can wreak havoc in the body, giving rise to cancer and other health problems. Yet sometimes cells rupture their own DNA for a good reason.
Cell & Microbiology
Apr 17, 2017
0
6
A streamlined protocol for an alternative gene insertion method using genome editing technologies, the PITCh (Precise Integration into Target Chromosome) system, has been reported in Nature Protocols by Specially Appointed ...
Biotechnology
Dec 17, 2015
0
5
A group of researchers led by Tomoji Mashimo, Associate Professor, Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University and Kazuto Yoshitomi, Assistant Professor, Mouse Genomics Resource ...
Biotechnology
Mar 24, 2016
0
2
Scientists from A*STAR's Bioinformatics Institute (BII) have developed an analytical model and computational tool to rapidly and accurately predict the occurrence and locations of R-loop Forming Sequences (RLFSs) in any genome ...
Biotechnology
May 29, 2015
0
22
Reconstitution of the activation of the MLH1–MLH3 endonuclease shows how crossovers are formed during meiosis.
Molecular & Computational biology
Aug 20, 2020
0
2
Increased sea temperatures could dramatically enhance and accelerate radiation-induced DNA effects in marine invertebrates, a new study suggests.
Environment
Aug 23, 2016
0
0
In the gonads of animals, genome parasites such as transposons pose a serious threat to evolutionary fitness. With their ability to bounce around in the genome, they often cause dangerous mutations. To protect genomic integrity, ...
Biotechnology
Jun 4, 2013
0
0
Numerous anti-cancer drugs function by targeting the DNA within cancerous cells, halting their proliferation. Yet, cancer cells occasionally develop mechanisms to repair the damage inflicted by these drugs, diminishing their ...
Molecular & Computational biology
Mar 12, 2024
0
2
Our DNA undergoes constant damage and repair. The most severe damage happens when the DNA breaks into two pieces, known as a double-strand DNA break. It creates two loose DNA ends that, if left unfixed, can lead to cell death. ...
Cell & Microbiology
Feb 6, 2024
0
49
