All cells are confronted with DNA damage, for example by exposure of the skin to UV rays, chemical byproducts of nerve cells consuming sugar, or immune cells destroying bacteria. If these DNA lesions are not - or badly - ...
Cell & Microbiology
Jun 13, 2017
0
183
We often come to an understanding of what causes a disease. We know, for example, that cancers are caused by mutations at critical locations in the genome, resulting in loss of control of cell growth. We know that the onset ...
Molecular & Computational biology
May 10, 2023
0
67
A team of scientists led by Dr. Kei-ichi Takata from the Center for Genomic Integrity (CGI) within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover ...
Cell & Microbiology
Mar 16, 2023
0
53
Researchers from several Russian institutes, including MIPT, have found out how prolonged exposure to ionizing radiation affects human stem cells. They discovered that it causes a cell cycle delay, which leads to faster repairs ...
Cell & Microbiology
Aug 25, 2017
0
6
A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.
Cell & Microbiology
Oct 24, 2022
0
23
From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this ...
Molecular & Computational biology
Apr 15, 2021
0
150
Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of ...
Biotechnology
Jun 4, 2015
0
17
BRCA1, a protein that is well-known for its role in hereditary breast cancer, is an important part of the cellular system that repairs double-strand DNA breaks. Now, researchers from Japan have discovered a new way in which ...
Biotechnology
Jul 13, 2021
0
11
A team of scientists has identified how damaged DNA molecules are repaired inside the human genome, a discovery that offers new insights into how the body works to ensure its health and how it responds to diseases that stem ...
Molecular & Computational biology
Dec 5, 2019
0
24
Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine have discovered that in eukaryotic cells, the proximity of the genes to the pores in the nuclear membrane ...
Cell & Microbiology
Nov 17, 2017
0
129
