Molecular brake on human cell division prevents cancer

Researchers at Karolinska Institutet, Sweden, and the University of Sussex, England, have discovered that the process of copying DNA generates a brake signal that stalls cell division. This molecular brake ensures that the ...

DNA replication in HPV

A pair of researchers from the University of Delaware Department of Medical and Molecular Sciences are investigating genetic variations in DNA replication of human papillomaviruses (HPV) and its correlation with HPV-related ...

Researchers build DNA replication in a model synthetic cell

Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure. Creating ...

Mixing and matching yeast DNA

Osaka University scientists show molecular factors that determine why some regions in yeast chromosomes are apt for remodeling, while other regions stay faithful during cell replication.

Many forks make light work

New insights into the control of DNA replication and cell division in Corynebacterium glutamicum, a biotechnologically important microorganism, could help to optimize the industrial production of amino acids.

Excessive DNA replication and its potential use against cancer

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, ...

New protein regulated by cellular starvation

Researchers at the Center of Genomic Integrity, within the Institute for Basic Science (IBS), have found out an unexpected role for a protein involved in the DNA repair mechanism. The protein SHPRH not only helps to fix mistakes ...

Enzyme with high potential for new cancer treatment identified

A team of researchers from the Biology department at the TU Darmstadt has identified an enzyme that separates DNA replication from repair. This discovery could be of tremendous significance in the treatment of tumours. The ...

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