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Researchers develop world's most productive chemical synthesis of anthracimycin

HKUST researchers develop world's most productive chemical synthesis of anthracimycin
The novel chemical synthesis of anthracimycin devised by Prof. Tong and his team. Credit: HKUST

A research team from the Hong Kong University of Science and Technology (HKUST) has developed the world's most productive chemical synthesis, which could yield antibiotic anthracimycin and anthracimycin B that is 63 times more prolific than the current method. The breakthrough greatly advances the development of anthracimycin-based antibiotics to combat deadly bacteria infections caused by antibiotic-resistant bacteria and even superbugs.

Since its discovery from an ocean microbe a decade ago, anthracimycin has drawn the attention of scientists around the world for its potential to combat Gram-positive bacteria, including the notorious methicillin-resistant Staphylococcus aureus (MRSA) and the bacterium Bacillus anthracis.

Among the pathogens, MRSA is known for causing staph infections that are difficult to treat because of the bacteria's resistance to some commonly used antibiotics such as penicillin. While scientists have been making efforts to develop anthracimycin into a new clinical antibiotic to address the mounting threat of antibiotic resistance and treatment failure, their progress is hindered by anthracimycin's lack of availability.

Now, a team led by Prof. Tong Rongbiao, Associate Professor of the Department of Chemistry at HKUST and Prof. Qian Peiyuan, Chair Professor of Department of Ocean Science at HKUST, has designed a productive chemical synthesis strategy that could greatly boost the yield of anthracimycin. Consisting of just ten steps, the world's shortest synthesis route not only produces 63 times more anthracimycin than the current method, but also brings down the cost due to the lower amount of reagent and solvent needed during the .

HKUST researchers develop world's most productive chemical synthesis of anthracimycin
A research team led by Prof. Tong Rongbiao, Associate Professor of the Department of Chemistry at HKUST (middle). Credit: HKUST

In addition, the team has also verified for the first time that anthracimycin could inhibit the formation of MRSA biofilms. Compared to , which was regarded as the last-line defense against serious infections caused by Gram-positive bacteria, lower concentrations of anthracimycin are needed for killing or inhibiting .

Prof. Tong said, "Our novel chemical synthesis overcomes the fundamental bottleneck of limited availability of anthracimycin and enables the scientists to further study its antibiotic activity, laying the groundwork for clinical drug development. Currently, we are collaborating with a biological laboratory to synthesize a set of anthracimycin antibiotics in the hope of identifying the combination with better antibacterial activity for possible further clinical trials."

The findings were recently published in Chemical Science.

More information: Peilin Tian et al, Ten-step asymmetric total syntheses of potent antibiotics anthracimycin and anthracimycin B, Chemical Science (2022). DOI: 10.1039/D2SC05049H

Journal information: Chemical Science

Citation: Researchers develop world's most productive chemical synthesis of anthracimycin (2023, March 8) retrieved 22 June 2024 from https://phys.org/news/2023-03-world-productive-chemical-synthesis-anthracimycin.html
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