Turning light energy into heat to fight disease

Turning light energy into heat to fight disease
Sensing the size-dependent light-to-heat conversion efficiency of nanoparticles by terahertz radiation. Credit: Roberto Morandotti

An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. For example, photothermal therapy, a new type of cancer treatment, involves aiming infrared laser light onto nanoparticles near the treatment site.

Localized heating in these systems must be carefully controlled since living tissue is delicate. Serious burns and tissue damage can result if unwanted heating occurs in the wrong place. The ability to monitor is crucial in developing this technology. Several approaches have been tried, but all of them have drawbacks of various kinds, including the need to insert probes or inject additional materials.

In this week's issue of APL Photonics scientists report the development of a new method to measure temperatures in these systems using a form of known as . The study involved suspensions of gold nanorods of various sizes in water in small cuvettes, which were illuminated by a laser focused on a small spot within the cuvette.

The tiny gold rods absorbed the laser light and converted it to heat that spread through the water by convection. "We are able to map out the temperature distribution by scanning the cuvette with terahertz radiation, producing a thermal image," co-author Junliang Dong said.

The study also looked at the way the temperature varied over time. "Using a , we are able to calculate the efficiency by which the gold nanorod suspensions converted infrared light to heat," said co-author Holger Breitenborn.

The smallest gold particles, which had a diameter of 10 nanometers, converted laser light to heat with the highest efficiency, approximately 90%. This value is similar to previous reports for these gold particles, indicating the measurements using terahertz radiation were accurate.

Although the smaller gold rods had the highest light-to-heat conversion efficiency, the largest rods—those with a diameter of 50 nanometers—displayed the largest molar heating rate. This quantity has been recently introduced to help evaluate the in biomedical settings.

"By combining measurements of temperature transients in time and thermal images in space at terahertz frequencies, we have developed a noncontact and noninvasive technique for characterizing these nanoparticles," co-author Roberto Morandotti said. This work offers an appealing alternative to invasive methods and holds promise for biomedical applications.

More information: H. Breitenborn et al, Quantifying the photothermal conversion efficiency of plasmonic nanoparticles by means of terahertz radiation, APL Photonics (2019). DOI: 10.1063/1.5128524

Citation: Turning light energy into heat to fight disease (2019, December 17) retrieved 30 November 2022 from https://phys.org/news/2019-12-energy-disease.html
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