Pathogenic, drug-resistant bacteria found in wastewater treatment plants

Pathogenic, drug-resistant bacteria found in wastewater treatment plants
Wastewater settlement tank. Credit: Theo Gouliouris

Infections caused by drug-resistant bacteria are a global public health threat causing serious illness and even death. Strains of the bacterium Enterococcus faecium (E. faecium) are generally harmless in healthy people, but can be pathogenic in immunocompromised or severely ill patients. E. faecium strains from hospital environments have acquired resistance to commonly used antibiotics, including those used to treat serious infections, making these infections especially challenging to treat.

In a study published today in Genome Research, researchers conducted a survey of 20 municipal wastewater plants in England, and isolated drug-resistant E. faecium from all sites in both untreated and treated wastewater plants except three, which use ultraviolet light disinfection. Importantly, drug-resistant E. faecium counts were significantly higher in untreated wastewater from plants that were direct recipients of hospital sewage. A genomic comparison of E. faecium isolates from wastewater and bloodstream isolates of infected patients revealed two major lineages, with ampicillin-resistant bacteria in clade A1 and A2 and vancomycin-resistant bacteria exclusive to clade A1. Further revealed the presence of shared antibiotic, metal, and biocide resistance genes in clade A1 isolates from bloodstream, hospital sewage, and municipal wastewater.

This study demonstrates close genetic relatedness of drug-resistant E. faecium isolates released into the environment with those that cause serious human disease. Further research is needed to determine the public health implications of exposure to healthcare- and waste-associated pathogens. Terminal ultraviolet light disinfection of is one solution that would reduce environmental contamination with .


Explore further

Germs gaining resistance to hand gels in hospitals

More information: Gouliouris T, Raven K, Moradigaravand D, Ludden C, Coll F, Blane B, Naydenova P, Horner C, Brown N, Corander J, Limmathurotsakul D, Parkhill J, and Peacock S. 2019. Detection of vancomycin-resistant Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment. Genome Research DOI: 10.1101/gr.232629.119
Journal information: Genome Research

Provided by Cold Spring Harbor Laboratory Press
Citation: Pathogenic, drug-resistant bacteria found in wastewater treatment plants (2019, March 21) retrieved 23 May 2019 from https://phys.org/news/2019-03-pathogenic-drug-resistant-bacteria-wastewater-treatment.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
12 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more