Natural-based antibiofilm and antimicrobial peptides from microorganisms

January 2, 2019, Bentham Science Publishers
Credit: CC0 Public Domain

New developments in antimicrobial peptides (AMPs) with antibiofilm properties are rapidly materializing. ABP works by inhibiting antibiotic resistant bacteria in the biofilm through nucleotide signaling molecules.

Antimicrobial peptides and antibiofilm peptide (ABP) are new antibiotic molecules derived from microorganisms for the treatment of infections. The authors have discussed significance, limitations and trials of these antimicrobial peptides from bacteria, fungi, protozoa and yeast.

These antimicrobial peptides are small, cationic and amphipathic polypeptide sequences with a wide range for Gram-positive and Gram-negative bacteria, viruses and fungi with 6-100 in length. These sources are reviewed in detail showing characterization of these and their respective classes.

The APD3 database showed 333 bacteriocin and peptide antibiotics from bacteria, 4 fromarchaea, 8 from protists, 13 from fungi are reported. Bacterial AMP are characterized according to their amino acid numbers and are so small in size with 1-5 kDa mass as compared to Class II AMPs are longer with amino acid number is about 25-50.

Class II bacteriocins are composed of homogeneous amino acids and classified into different groups based on their secondary structure. Class II Lactococcin produced by Lactococcus lactis is Lactococcin B. This AMP is involved in changes of membrane potential.

The reported fungal AMP compounds are more than bacterial AMP and found to be a good source of antimicrobial compounds discovery against infections due to similarity in features and responses to infections.

The in silico cDNA scanning method is widely used for determining the sequencing of Defensin like peptides and more than 100 AMP's are revealed with the help of genome screening approaches.

Fungal AMP's Peptaibols isolated as from possesses anti-microbial and anti-fungal activities. They have short amino acid chains.

Explore further: Engineers repurpose wasp venom as an antibiotic drug

More information: Aysenur Yazici et al, Natural-based Antibiofilm and Antimicrobial Peptides from Microorganisms, Current Topics in Medicinal Chemistry (2018). DOI: 10.2174/1568026618666181112143351

Related Stories

Engineers repurpose wasp venom as an antibiotic drug

December 7, 2018

The venom of insects such as wasps and bees is full of compounds that can kill bacteria. Unfortunately, many of these compounds are also toxic for humans, making it impossible to use them as antibiotic drugs.

Remedy against superbacteria found in crowberry

November 5, 2018

Researchers in Oulu have found small fragments of an antibacterial protein, also known as peptides, in a microbe living in crowberry. The peptide is able to destroy bacteria that cause infections. Based on the peptide, a ...

Computers learn to recognize molecules that can enter cells

November 15, 2016

A team of researchers from UCLA and the University of Illinois at Urbana-Champaign originally set out to discover and design antimicrobial peptides—short chains of amino acids that can kill bacteria by punching holes in ...

Recommended for you

The powerful meteor that no one saw (except satellites)

March 19, 2019

At precisely 11:48 am on December 18, 2018, a large space rock heading straight for Earth at a speed of 19 miles per second exploded into a vast ball of fire as it entered the atmosphere, 15.9 miles above the Bering Sea.

Revealing the rules behind virus scaffold construction

March 19, 2019

A team of researchers including Northwestern Engineering faculty has expanded the understanding of how virus shells self-assemble, an important step toward developing techniques that use viruses as vehicles to deliver targeted ...

Nanoscale Lamb wave-driven motors in nonliquid environments

March 19, 2019

Light driven movement is challenging in nonliquid environments as micro-sized objects can experience strong dry adhesion to contact surfaces and resist movement. In a recent study, Jinsheng Lu and co-workers at the College ...

Levitating objects with light

March 19, 2019

Researchers at Caltech have designed a way to levitate and propel objects using only light, by creating specific nanoscale patterning on the objects' surfaces.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.