A new method to pinpoint genetic differences between species could benefit human health

October 8, 2018, Buck Institute for Research on Aging
Female mole rat. Credit: Jedimentat44/flickr/CC BY 2.0

Why do naked mole rats live up to 31 years, when distantly related lab mice are lucky to make it to four? How is the aquatic axolotl capable of regenerating limbs, jaws, spines and even brains when frogs can only regrow tails as tadpoles? How can these difference be exploited for the benefit of human health?

Questions like these set up a classic starting point for . When a trait catches a geneticist's eye, the goal is always to find the DNA sequence differences that underlie it. But to date, the tools of the field have focused on individuals of a population—what makes one human different from another, for example, when we are all the same . Trait differences between species have been essentially out of reach.

Now researchers at the Buck Institute have broken through this roadblock by designing a method that pinpoints genetic causality for trait differences between closely related species. The research, published in Nature Genetics, lays the groundwork for the mapping of specific genes to specific traits in sister species throughout the plant and animal kingdoms.

"Think of all the amazing characteristics we see in organisms around us, from longevity and disease resistance to the spots on a butterfly," said Rachel Brem, Ph.D., associate professor at the Buck Institute for Research in Aging. "We want to find the genes at the root of these traits, and in many cases, they'll be relevant for ."

As an example, Brem points out that there are mouse species with stark differences in longevity, immunity, susceptibility to cancer, and the ability to recover from brain injury, among others. "Now we'll be able to find the genetic basis for those advantages and start comparing the findings with human genetics." Brem says the method is being utilized in multiple labs at the Buck, where the ultimate goal is to design drugs that mimic, in humans, the best that the natural world has to offer.

The new method, which Brem says is straightforward and simple, was developed by genetically dissecting an ancient divergence in two species of yeast that differed in their tolerance to heat. In addition to research involving human health, Brem says the work has wide applicability to plant biology and agriculture, as well as climate change as scientists seek to understand how animals adapt to extreme environments.

"Evolutionary geneticists are interested in 'outliers' - plants and animals that developed unusual traits as they evolved to survive and thrive in new environments and conditions," said Brem. "There's a lot left to be discovered and we're hoping that our work will provide a jump start to that process."

Explore further: A new method furthers understanding of evolutionary genetics

More information: Carly V. Weiss et al, Genetic dissection of interspecific differences in yeast thermotolerance, Nature Genetics (2018). DOI: 10.1038/s41588-018-0243-4

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5 / 5 (1) Oct 08, 2018
i think a better picture than that mole could have been used for this article
1 / 5 (3) Oct 08, 2018
START with Visible Feather Colors among various Bird genera.
Move Genes for the Feature around !
Most importantly, transfer ForEver-Living Tardigrade's Genes around among all species except to humans !
1 / 5 (2) Oct 09, 2018
START with Visible Feather Colors among various Bird genera.
Move Genes for the Feature around !
Most importantly, transfer ForEver-Living Tardigrade's Genes around among all species except to humans !

How Wonderful it will be, if we see Peacock Feathers in some other Bird (There are thousands of Varieties of them). It is NOT a joke. For Emancipation of Biochemistry AND Genetics, it is a must. We just use Genes of Peacock Cell to introduce into 1-Celled Zygote of a DIFFERENT Bird. If it Clicks, IT IS GREAT !
AND Try to Clothe the Naked Mole Rat WITH FUR !
not rated yet Oct 09, 2018
So be, you wistfully wish that your neighborhood pigeons (the flying kind, not the church-going kind) to have genegineered in peacock feathers?

Uhmm, suppose that'd be a pretty sight? At least up until your neighbors discover that the lovely feathers are produced by a bundle of peacock multi-purpose genes. That include raucously loud shrieks and a pugnacious nature.

Just think, your neighbors could revive that fine, old American tradition of tar and feathering a miscreant. Imagine how pretty you will look with all those peacock-pigeon feathers stuck on you!
1 / 5 (1) Oct 09, 2018
Oy, that was a practically complex simple-in-principle method. They put the alleles - gene variants - on (haploid) transposons, and chose strains were the transposons are inserted into genes and can be expressed. So now they need to compare growth of transposons knockouts (because at least one gene is inactivated) and non-knockouts, then compare the growth results between the alleles.

But it works!

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