Bacteria-fighting polymers created with light

August 14, 2018, University of Warwick
Credit: CC0 Public Domain

Hundreds of polymers that could kill drug-resistant superbugs in novel ways can be produced and tested with light, using a method developed at the University of Warwick. The new methodology may identify antimicrobials for a range of applications from personal care to coatings.

Researchers from the Department of Chemistry and Warwick Medical School developed a way to synthesise large libraries of polymers to make screening for antimicrobial activity faster, and without the need to use sealed vials.

By using multiple 'building blocks' in their polymers, new antimicrobials were identified – some of which appear to inhibit bacteria growth, contrary to predictions. The benefit of the method is that it allows screening of hundreds of different structures, enabling the researchers to 'go fishing' for new properties, which in this case was antibiotic activity.

Antimicrobials are essential not just in the treatment of internal disease and infections, but also in personal care products, such as contact lenses or shampoo, in foods, or as topical creams.

There is growing awareness of antimicrobial resistance and the need to develop innovative solutions to tackle microbial infection.

Traditional anti-microbials (such as penicillin) work by inhibiting key cellular processes. The Warwick team, led by Professor Matthew Gibson, were instead inspired by host-defence peptides which are broad spectrum antimicrobials and function by breaking apart the membrane of bacteria.

Professor Matthew Gibson from Warwick's Department of Chemistry and Warwick Medical School, also lead author of the paper, said:

"Whilst many people have successfully mimicked antimicrobial peptides with polymers, the limiting step was the number of different combinations of building blocks you can use. We used simple robotics and a light controlled polymerisation, which lets us do the chemistry open to air, without any sealed vials which are essential for most polymer syntheses."

Dr. Sarah-Jane Richards, from the Gibson Group at the University of Warwick and the lead author of the work, said: "We prepared the polymers in such a way that at the end of the reaction, we use the robotics to mix polymers directly with bacteria so we could look for unexpected activity, which we achieved. Surprisingly, the best materials do not seem to break apart the bacteria as we predicted, but rather inhibit their growth. We are investigating this further."

The research is published in Chemistry: A European Journal.

Explore further: Nature's antifreeze inspires revolutionary bacteria cryopreservation technique

More information: Sarah-Jane Richards et al, Photochemical 'In-Air' Combinatorial Discovery of Antimicrobial Copolymers, Chemistry - A European Journal (2018). DOI: 10.1002/chem.201802594

Related Stories

Novel therapies for multidrug-resistant bacteria

October 23, 2017

During this innovative study published in PLOS One, researchers found that novel classes of compounds, such as metal-complexes, can be used as alternatives to or to supplement traditional antibiotics, which have become ineffective ...

Recommended for you

A hydrogel that adheres firmly to cartilage and meniscus

November 21, 2018

EPFL researchers have developed a hydrogel – made up of nearly 90% water – that naturally adheres to soft tissue like cartilage and the meniscus. If the hydrogel carries repair cells, it could help damaged tissue to heal.

DNA origami full of potent anticancer agents

November 21, 2018

One of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance. Chinese scientists have now developed a nanoplatform that selectively ...

Removing toxic mercury from contaminated water

November 21, 2018

Water contaminated with mercury and other toxic heavy metals is a major cause of environmental damage and health problems worldwide. Now, researchers from Chalmers University of Technology, Sweden, present a totally new way ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.