Repair and regeneration of peripheral nerves possible with dual polymer hydrogel adhesive

June 14, 2018, Mary Ann Liebert, Inc
Tissue Engineering brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Credit: Mary Ann Liebert, Inc., publishers

Researchers have demonstrated that a novel biocompatible adhesive made of two naturally derived polymers is 15 times stronger than adhesive materials currently used for nerve reconstruction and can support the survival, extension, and proliferation of cells essential for nerve regeneration. The study showing the regenerative potential of this new hydrogel adhesive in vitro and when implanted in a mouse model of suture-less repair of sciatic nerves is published in Tissue Engineering, Part A.

Ryan Koppes, Northeastern University (Boston, MA), Nasim Annabi, Northeastern U. and Massachusetts Institute of Technology (Cambridge, MA), and coauthors from Tecnológico de Monterrey (Mexico) and University of Sydney (Australia) describe the materials and technique they developed in the article entitled "Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair." The researchers used photocrosslinking to combine two polymers with distinct biophysical and biochemical characteristics to form the adhesive hydrogel. This produced a material with improved adhesive strength compared to conventional fibrin-based adhesives, and with the desired mechanical stability, nerve regenerative capability, and biodegradable and immunogenic properties.

"This article presents the development of a regenerative biomaterial that has designer mechanical properties and adhesive characteristics and addresses an important clinical need for ," says Tissue Engineering Co-Editor-in-Chief Antonios G. Mikos, Ph.D., Louis Calder Professor at Rice University, Houston, TX.

Explore further: Research team creates hydrogel adhesives to seal wounds

More information: Jonathan R. Soucy et al, Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair, Tissue Engineering Part A (2018). DOI: 10.1089/ten.tea.2017.0502

Related Stories

Research team creates hydrogel adhesives to seal wounds

March 9, 2018

A Band-Aid adhesive bandage is an effective way to stop bleeding from skin wounds, but an equally viable option for internal bleeding does not yet exist. Surgical glues are often used inside the body instead of traditional ...

Inorganic biomaterials for soft-tissue adhesion

June 29, 2017

Researchers at Okayama University describe in Acta Biomaterialia a new type of biocompatible adhesive material. The adhesive, made from nanoparticles of hydroxyapatite, glues both synthetic hydrogels and mouse soft tissue, ...

Oysters: one animal, two glues

May 7, 2018

Oysters build extensive reef communities by cementing to one another early in their lives. Scientists have known they secrete an adhesive for this purpose, but new research shows the glue they make as babies and juveniles ...

Recommended for you

Template to create superatoms could make for better batteries

June 21, 2018

Virginia Commonwealth University researchers have discovered a novel strategy for creating superatoms—combinations of atoms that can mimic the properties of more than one group of elements of the periodic table. These superatoms ...

Researchers achieve unprecedented control of polymer grids

June 21, 2018

Synthetic polymers are ubiquitous—nylon, polyester, Teflon and epoxy, to name just a few—and these polymers are all long, linear structures that tangle into imprecise structures. Chemists have long dreamed of making polymers ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.