A simple mechanism could have been decisive for the development of life

May 24, 2018, Technical University Munich
A team at the Technical University of Munich (TUM) has shown for the first time, that phase separation is an extremely efficient way of controlling the selection of chemical building blocks, providing advantages to certain molecules. This simple mechanism could have been decisive for the development of life. Left: clear solution; right: inside the tiny oil droplets instable molecules survive longer. Credit: Andreas Battenberg / TUM

The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and providing advantages to certain molecules.

Without energy, cells cannot move or divide, and cannot maintain even basic functions such as the production of simple proteins. If energy is lacking, more complex connections disintegrate quickly, and early life would have died off immediately.

Chemist Job Boekhoven and his team at TUM have now succeeded in using to find a mechanism in simple that enables extremely unstable molecules such as those found in the to have a higher degree of stability. They could survive longer, even if they had to survive a period without external energy supply.

The principle of simplicity

Job Boekhoven and his team were looking for a simple mechanism with primitive molecules that could produce lifelike properties. "Most likely, molecules were simple in the primordial soup," says Boekhoven. The researchers investigated what happened when they fed various carboxylic acid molecules with high-energy carbodiimide condensing agents, thus bringing them out of equilibrium.

The reaction produced unstable anhydrides. Mostly, these non-equilibrium products quickly disintegrate into carboxylic acids again. The scientists showed that the anhydrides that survived the longest were those that could form a kind of oil droplet in the aqueous environment.

Single droplets under a fluorescence microscope. Credit: Marta Tena-Solsona / TUM
Molecules in the garage

The effect can also be seen externally—the initially clear solution became milky. The lack of water in the oil droplets conferred protection, because anhydrides need water to disintegrate back into carboxylic acids.

Boekhoven explains the principle of phase separation with an analogy: "Imagine an old and rusty car. Leave it outside in the rain, and it continues to rust and decomposes because rusting is accelerated by water. Put it in the garage, and it stops rusting, because you separate it from the rain."

In a way, a similar process occurs in the primordial soup experiment. Inside the oil droplet (garage) with the long-chain anhydride molecules there is no water, so its molecules survive longer. If the molecules compete with each other for energy, those that can protect themselves by forming oil droplets are likelier to survive, while their competitors get hydrolyzed.

Next goal: viable information carriers

Since the mechanism of phase separation is so simple, it can possibly be extended to other types of molecular aggregations with lifelike properties, such as DNA, RNA or self-dividing vesicles. Studies have shown that these bubbles can divide spontaneously. "Soon we hope to turn primitive chemistry into a self-replicating information carrier that is protected from decay to a certain extent," says Boekhoven.

Explore further: Supramolecular materials with a time switch

More information: Marta Tena-Solsona et al, Self-selection of dissipative assemblies driven by primitive chemical reaction networks, Nature Communications (2018). DOI: 10.1038/s41467-018-04488-y

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