Potential insecticide discovered in Earth's longest animal

Potential insecticide discovered in Earth's longest animal


Bootlace worm. Credit: University of Queensland

A family of potent protein neurotoxins have been discovered in bootlace worms, a University of Queensland researcher has found.

Found in the northern hemisphere and reaching up to 55 metres in length, bootlace were investigated as part of a neglected group of with poorly understood chemistry.

UQ researcher Dr. Johan Rosengren said animal toxins had a wide range of commercial applications.

"Proteins from marine snails, snakes, spiders, and scorpion venoms have been used as drugs, pharmacological tools, and within biotechnology and agriculture," Dr. Rosengren said.

"The most potent of the new toxins identified produces effects in invertebrates similar to tetrodotoxin, a well-known toxin sourced from puffer fish which causes paralysis.

"This makes it a potentially ideal insecticidal toxin."

The toxin, known as nemertide α-1, was identified in the large amounts of thick mucus the worm produced when provoked.

"We isolated the most abundant toxin protein from the mucus and found that its injection causes paralysis and death in green crabs and juvenile cockroaches," Dr. Rosengren said.

"When compared to similar toxins from spiders, nemertide α-1 is at least three times more potent for a comparable dose."

"We also showed that the isolated prevents the inactivation of invertebrate sodium channels in three distinct insect species: the German cockroach, the common fruit fly and the varroa mite."

"Lots of work remains in order to fully characterise these peptides, but we hope to find out if we can use the defense molecules from the bootlace worms to control insect pests that destroy crops and spread disease."

The study is published in Scientific Reports.


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More information: Erik Jacobsson et al. Peptide ion channel toxins from the bootlace worm, the longest animal on Earth, Scientific Reports (2018). DOI: 10.1038/s41598-018-22305-w
Journal information: Scientific Reports

Citation: Potential insecticide discovered in Earth's longest animal (2018, March 23) retrieved 17 June 2019 from https://phys.org/news/2018-03-potential-insecticide-earth-longest-animal.html
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