A greener way to make ketones
Researchers at McGill University have discovered a new, more environmentally friendly way to make ketones, an important chemical ingredient in pharmaceuticals. While ketones are found in a wide range of useful chemicals, they are commonly prepared through energy-intensive, multi-step technologies that create significant chemical waste.
In an article published online last month in Nature Chemistry, the McGill scientists demonstrate how carbon monoxide, a widely available by-product of combustion, can instead be used to form high-energy chemicals that react directly with benzene to generate ketones.
"This approach could offer a new and green method to activate readily available, but inert hydrocarbons, and use them to make a variety of valuable products," says McGill chemistry professor Bruce Arndtsen, senior author of the study.
More information: R. Garrison Kinney et al. A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation, Nature Chemistry (2017). DOI: 10.1038/nchem.2903
Journal information: Nature Chemistry
Provided by McGill University