Cell-derived drug delivery systems

December 4, 2017, National University of Singapore
Cell-derived drug delivery systems
Schematic demonstrating the production of CDNs. CDNs can be produced “on-demand” in larger quantities within a shorter time frame than isolating the same amount of exosomes. Credit: National University of Singapore

NUS pharmaceutical scientists have developed a cost-effective method to produce cell-derived nanovesicles (CDNs) for bio-inspired drug delivery applications.

Drug Delivery Systems (DDS) play an important role in transporting drugs to their intended target sites. They protect the active pharmaceutical compounds from the external environment during their journey to the target tissues, resulting in more effective treatment and lower drug amounts. Several synthetic DDS have been developed in recent years, but they are often limited by their accumulation in the body, hence resulting in greater potential toxicity profiles, especially if the drug cannot reach the diseased area in sufficient amounts.

Interestingly, naturally produced nanoscale cellular structures (vesicles), namely exosomes, are released by almost all mammalian . Exosomes have emerged as potential candidates for use as DDS due to their low toxicity (in view of their natural origin), ability to house biological cargo and propensity to accumulate within diseased tissue (due to the preservation of key surface features from their parent cells). However, their translation into clinical applications is limited by the multi-step approach needed to isolate naturally secreted exosomes and its low yield.

Prof Giorgia PASTORIN and her Ph.D. student Wei Jiang GOH from the Department of Pharmacy, NUS, have developed a simple and cost-effective method to produce CDNs, which can mimic naturally occurring exosomes. The CDNs are produced by shearing cells into nanoscale vesicles by passing them through a series of filters using standard laboratory equipment. These CDNs have been shown to be similar to exosomes in terms of key proteins and lipid composition. Using this new method, CDNs can be produced "on demand" and in larger quantities as compared to isolating exosomes from the same amount of cells.

Prof Pastorin said, "We have demonstrated that these CDNs retain the ability to reach and accumulate at cancerous tissue in a mouse tumour model and have developed a for loading a chemotherapeutic into the CDNs."

Explore further: Tracking the body's mini-shuttles

More information: Wei Jiang Goh et al. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative, Scientific Reports (2017). DOI: 10.1038/s41598-017-14725-x

Wei Jiang Goh et al. Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy, International Journal of Nanomedicine (2017). DOI: 10.2147/IJN.S131786

Related Stories

Tracking the body's mini-shuttles

September 28, 2017

The development of a new technique for labelling the body's own transporters—exosomes—could have long term benefits in the treatment of life-threatening medical conditions, including cancer.

A step closer to a cure for adult-onset diabetes

October 23, 2017

In healthy people, exosomes – tiny structures secreted by cells to allow intercellular communication – prevent clumping of the protein that leads to type 2 diabetes. Exosomes in patients with the disease don't have the ...

New method delivers Alzheimer's drug to the brain

March 21, 2011

(PhysOrg.com) -- Oxford University scientists have developed a new method for delivering complex drugs directly to the brain, a necessary step for treating diseases like Alzheimer’s, Parkinson’s, Motor Neuron Disease ...

Recommended for you

X-ray triggered nano-bubbles to target cancer

July 16, 2018

Innovative drug filled nano-bubbles, able to be successfully triggered in the body by X-rays, have been developed by researchers, paving the way for a new range of cancer treatments for patients.

Smart window controls light and heat, kills microorganisms

July 13, 2018

A new smart window offers more than just a nice view—it also controls the transmittance of sunlight, heats the interiors of buildings by converting solar radiation into heat, and virtually eliminates E. coli bacteria living ...

Quantum dot white LEDs achieve record efficiency

July 12, 2018

Researchers have demonstrated nanomaterial-based white-light-emitting diodes (LEDs) that exhibit a record luminous efficiency of 105 lumens per watt. Luminous efficiency is a measure of how well a light source uses power ...

How gold nanoparticles could improve solar energy storage

July 12, 2018

Star-shaped gold nanoparticles, coated with a semiconductor, can produce hydrogen from water over four times more efficiently than other methods—opening the door to improved storage of solar energy and other advances that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.