Age of mothers influences genetic similarity between twins

November 30, 2017, Centre for Genomic Regulation
Caenorhabditis elegans worm with fluorescent yolk and embryos inside. Credit: Lola Davey, Marcos Francisco Perez, CRG

Does the age of a mother influence the traits and characteristics of her progeny, and how? A team of scientists at the Centre for Genomic Regulation (CRG) in Barcelona have addressed these questions by studying tiny, genetically identical C. elegans worms. Their results have been published today in Nature.

"Our lab has long been interested in understanding why genetically identical individuals sharing the same environment still often differ substantially in their characteristics," explains Ben Lehner, ICREA Professor and Coordinator of the Systems Biology Program at CRG. "Through a rather circuitous route, we have now identified a major cause of these differences in one of the main model organisms that we study."

"We observed that the age of a mother has a major impact on the physiology of her offspring," says Marcos Francisco Perez, PhD student and co-author of this work. "Surprisingly, we found that it is the youngest mothers that produce offspring that are impaired for many characteristics such as their size, growth rate, and starvation resistance The offspring of young also have fewer offspring themselves when they become adults," he adds.

Age of mothers influences genetic similarity between twins
Caenorhabditis elegans embryos containing fluorescent yolk from younger (left) to older mothers (right). Credit: Marcos Francisco Perez, CRG
"These differences are caused in part because provide less of a specific protein complex to their embryos," says Marcos Francisco Perez. Why would a worm produce low-quality progeny early in life? "Producing progeny early in life, even if they are lower quality, has a major benefit because it dramatically shortens the generation time of the species," explains Marcos Francisco Perez.

"What's particularly interesting is that the age of an individual's mother determines their characteristics throughout their lives," adds Ben Lehner. "This is a really interesting example of how the physiology of a previous generation can alter not only the development of an animal but also its characteristics as a mature adult."

Of worms and humans

Caenorhabditis elegans embryo showing yolk and intestinal fluorescence. Credit: Lola Davey, Marcos Francisco Perez, CRG

Ben Lehner and his team are interested in understanding what makes individuals different and how these differences originate in the interactions between genetic, environmental, ancestral and stochastic sources of variation. Worms are a great species to use in this type of study, because scientists can raise large populations of genetically identical individuals in the same laboratory environment. Worms and humans are evolutionarily distant but still share a large fraction of their genes, as well as most of the major genetic pathways which regulate development, metabolism and nutrition. Still, their results concerning the effect of maternal age do not translate to humans but illustrate the kind of ways in which differences between genetically identical individuals might arise.

"Our results are also important for the thousands of people doing research in this species. People don't consider when designing experiments but now we have shown that it is an important factor," conclude the scientists.

Explore further: Microbiome diversity is influenced by chance encounters

More information: Marcos Francisco Perez et al. Maternal age generates phenotypic variation in Caenorhabditis elegans, Nature (2017). DOI: 10.1038/nature25012

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