Russian scientists teach ultrasound find and kill cancer cells

March 16, 2017, National Research Nuclear University

A group of physicists and biologists from Russia under the supervision of Professor Viktor Timoshenko from the National Research Nuclear University MEPhI (Russia) has used silicone nanoparticles for highlighting and destroying cancer tumors with the help of the ultrasound, leaving healthy tissues unharmed. The study has been published in Nanotechnology.

"We have found a part-load mode for therapeutic treatment of cancer cells, which doesn't lead to massive explosion of cells but is largely reduced to the destruction of intracellular organs by nanoparticles," says Andrey Sviridov from the Lomonosov MSU. He says that covering the particles in a biopolymer doesn't worsen their acoustic properties, but leads to a better therapeutic effect.

Lately physicists, chemists, and nanotechnologists are developing new surgical and therapeutic methods that are conducted without body rupture and damaging of tissues and organs. For example, researchers have developed nanoparticles that are introduced into tumors and then heated with a laser. This destroys the cancer, but doesn't affect . A similar effect is caused by gene therapy and special medicines, preventing the growth of vessels in tumors and starving cancer cells.

Sviridov and his colleagues have created special silicone nanoparticles, which can also be used for studying and their destruction via ultrasound.

The main problem of such methods of cancer treatment is that ultrasound and nanoparticles often act indiscriminately, destroying not only , but also healthy cells. Moreover, such nanoparticles often too quickly dissolve inside the organism.

Timoshenko, Sviridov, and their colleagues have solved this problem, covering nanoparticles from porous silicone with a layer of dextran, a biopolymer from dextrose molecules. Such particles, the biologists claim, not only dissolve more slowly than their uncovered analogues, but shine under ultraviolet radiation, which allows their use to highlight researched tumors and cell samples.

The particles were via ultrasound separately and in the presence of nanoparticles on cancer cell cultures extracted from human larynx tumors.

As experiments have shown, "clear" ultrasound doesn't affect cancer cells, while its combination with nanoparticles kills them, destroying mitochondria and other organelles in cancer cells.

Apart from ultrasound strengthening, the can be used for delivery of medicines and other molecules inside healthy or . Heating with the help of or radio waves makes therapeutic molecules more mobile, which strengthens their efficiency. These techniques will need to pass a series of clinical tests on animals or volunteers over several years, and such experiments don't always end up positively.

Explore further: New method to diagnose cancer

More information: A P Sviridov et al. Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications, Nanotechnology (2017). DOI: 10.1088/1361-6528/aa5b7c

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Hyperfuzzy
not rated yet Apr 04, 2017
First, is it possible to define a destructive resonant energy to faulty-cell death high and good-cell death low within the audio spectrum or the differential between good & bad harmonically over the entire spectrum. What's out of tune? I would look over the entire spectrum, better build a model of the molecule. Pretty sure we can define a description somewhere. Ask someone to code it for you. The trick, is those oscillations of diametrical fields over each's center. Danger Will Robinson. It's simply a diametrical spherical fields, updated at the speed of light relative to its center. I would set C=1, no units, dimensionally, think of it as wavelength, i.e. QM + casualty, simpler equations.
Hyperfuzzy
not rated yet Apr 04, 2017
Note: The idea is any point may be calculated given a set of initial conditions, any set of initial conditions may define a state, manipulation of init or control. Within the space above. Since it represents reality, you can either show the wrinkles in the field as the charges move, or show the floor show. juz say'n
Hyperfuzzy
not rated yet Apr 04, 2017
So nano-bots could see affinities, thresholds, use of environment, ...

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