Scientists develop painless and inexpensive microneedle system to monitor drugs

Scientists develop painless and inexpensive microneedle system to monitor drugs
Researchers at UBC and the Paul Scherrer Institut (PSI) in Switzerland have created a microneedle drug monitoring system capable of both collecting fluid and performing an analysis to determine the concentration of vancomycin in a patient's bloodstream. Credit: Sahan Ranamukhaarachchi

Researchers at the University of British Columbia and the Paul Scherrer Institut (PSI) in Switzerland have created a microneedle drug monitoring system that could one day replace costly, invasive blood draws and improve patient comfort.

The new system consists of a small, thin patch that is pressed against a patient's arm during and measures drugs in their bloodstream painlessly without drawing any . The tiny needle-like projection, less than half a milimetre long, resembles a hollow cone and doesn't pierce the skin like a standard hypodermic needle.

"Many groups are researching microneedle technology for painless vaccines and drug delivery," said researcher Sahan Ranamukhaarachchi, a PhD student in UBC's faculties of applied science and pharmaceutical sciences, who developed this technology during a research exchange at PSI. "Using them to painlessly monitor drugs is a newer idea."

Microneedles are designed to puncture the outer layer of skin, which acts as a protective shield, but not the next layers of epidermis and the dermis, which house nerves, blood vessels and active immune cells.

The microneedle created by Ranamukhaarachchi and his colleagues was developed to monitor the antibiotic vancomycin, which is used to treat serious infections and is administered through an intravenous line. Patients taking the antibiotic undergo three to four blood draws per day and need to be closely monitored because vancomycin can cause life-threatening toxic side effects.

Scientists develop painless and inexpensive microneedle system to monitor drugs
Microneedles are designed to puncture the outer layer of skin, which acts as a protective shield, but not the next layers of epidermis and the dermis, which house nerves, blood vessels and active immune cells. Credit: Sahan Ranamukhaarachchi

The researchers discovered that they could use the fluid found just below the outer layer of skin, instead of blood, to monitor levels of vancomycin in the bloodstream. The microneedle collects just a tiny bit of this fluid, less than a millionth of a millilitre, and a reaction occurs on the inside of the microneedle that researchers can detect using an optical sensor. This technique allows researchers to quickly and easily determine the concentration of vancomycin.

"This is probably one of the smallest probe volumes ever recorded for a medically relevant analysis," said Urs Hafeli, associate professor in UBC's faculty of .

"The combination of knowhow from UBC and PSI, bringing together microneedles, microfluidics, optics and biotechnology, allowed us to create such a device capable of both collecting the fluid and performing the analysis in one device," said Victor Cadarso, a research scientist and Ambizione Fellow at PSI.


Explore further

Could dissolvable microneedles replace injected vaccines?

More information: Sahan A. Ranamukhaarachchi et al, Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes, Scientific Reports (2016). DOI: 10.1038/srep29075
Journal information: Scientific Reports

Citation: Scientists develop painless and inexpensive microneedle system to monitor drugs (2016, July 25) retrieved 22 August 2019 from https://phys.org/news/2016-07-scientists-painless-inexpensive-microneedle-drugs.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
25 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more