New method to detect off-target effects of CRISPR

Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in therapeutically ...

Fuel cells in bacteria

The exchange of nitrogen between the atmosphere and organic matter is crucial for life on Earth because nitrogen is a major component of essential molecules such as proteins and DNA. One major route for this exchange, discovered ...

Taming the genome's 'jumping' sequences

The human genome is fascinating. Once predicted to contain about a hundred thousand protein-coding genes, it now seems that the number is closer to twenty thousand, and maybe less. And although our genome is made up of about ...

BRB-seq: The quick and cheaper future of RNA sequencing

RNA sequencing is a technique used to analyze entire genomes by looking at the expression of their genes. Today, such genome-wide expression analyses are a standard tool for genomic studies because they rely on high-throughput ...

Multiple modes for selectivity of transmembrane transport

LMU researchers utilized a biophysical approach to understand how bacterial import proteins bind and selectively convey their cargoes across membranes. The results reveal an unexpectedly wide variety of transfer mechanisms.

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