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Molecular & Computational biology news
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers ...
Protein USP50 identified as key in DNA replication balance
A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study.
Molecular & Computational biology
55 minutes ago
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Scientists develop a new method to study gene function in cells and tissue
The Gaublomme lab has developed a new optical pooled screening approach called CRISPRmap, which enables the coupling of optical properties of single cells to targeted genetic perturbations. Optical phenotypes are typically ...
Biotechnology
2 hours ago
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Targeting 'undruggable' diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, ...
Molecular & Computational biology
Oct 11, 2024
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Scientists discover how innate immunity envelops bacteria
The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has ...
Cell & Microbiology
Oct 11, 2024
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Hidden in the teeth: DNA study finds these 19th century lions preyed on humans and giraffes
In 1898, two male lions terrorized an encampment of bridge builders on the Tsavo River in Kenya. The lions, which were massive and maneless, crept into the camp at night, raided the tents and dragged off their victims. The ...
Ecology
Oct 11, 2024
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Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death.
Cell & Microbiology
Oct 11, 2024
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Intra-molecular distances in biomolecules measured optically with Ångström precision
A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within ...
Molecular & Computational biology
Oct 11, 2024
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Advanced model predicts gene architecture via nucleosome position
DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently. Nucleosomes facilitate DNA compaction and also play a ...
Molecular & Computational biology
Oct 10, 2024
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Claustrophobic cells slow their own growth, forming beautiful patterns of concentric circles
Like so many organisms on the planet, when cells experience mosh-pit-level crowding, they may just become stressed. Yet unlike most other life forms, cells subject to physical stress from crowding by neighbors can find some ...
Cell & Microbiology
Oct 10, 2024
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Key gene discovered for regulating rice grain length
Recently, a research team led by Professor Wu Yuejin from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, discovered a key gene that can influence rice grain length by regulating cell proliferation, ...
Molecular & Computational biology
Oct 10, 2024
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Benchmarking study aims to assist scientists in analyzing spatial transcriptomics data
A team of Vanderbilt researchers has released a new benchmarking study that aims to assist scientists in selecting the most effective methods for analyzing spatial transcriptomics (ST) data.
Molecular & Computational biology
Oct 10, 2024
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Targeting 'selfish' bacteria could optimize inhibitors that fight antibiotic resistance
As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment option.
Cell & Microbiology
Oct 10, 2024
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High-resolution structural data shows how a supercomplex links mRNA translation and decay
Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena Conti and her team at the Max Planck Institute of Biochemistry in Martinsried near Munich have now ...
Molecular & Computational biology
Oct 10, 2024
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AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University ...
Molecular & Computational biology
Oct 10, 2024
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From chaos to structure: How a bunch of seemingly disorganized cells go on to form a robust embryo
Pipetting liquids into tiny test tubes, analyzing huge datasets, poring over research publications—all these tasks are part of being a scientist. But breaking this routine is essential. Time away from the usual work environment ...
Cell & Microbiology
Oct 10, 2024
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Biomolecular condensates can split membranes without the aid of proteins, study finds
Researchers have found that cellular droplets function in more diverse ways than previously known. The ability to fission membranes in cells was previously attributed solely to certain proteins. In a new publication in Nature, ...
Cell & Microbiology
Oct 10, 2024
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Lighting the way with accurate and safe 3D embryo imaging
The inability to accurately predict embryo viability prior to implantation is a key contributor to the low success rate of clinical in-vitro fertilization (IVF), but a team of experts is highlighting a safe way to study embryos ...
Cell & Microbiology
Oct 10, 2024
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Genetic mechanism unlocks a key secret behind disease infection in crops
Researchers have unraveled a key genetic mechanism behind the way pathogens infect crops, leading to new strategies for breeding resistant crop varieties against other pathogens carrying the same genetic mechanism.
Molecular & Computational biology
Oct 10, 2024
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Sludge sequencing: High-throughput single-cell method reveals novel species and genetic diversity
Activated sludge is essential for removing contaminants from wastewater, and understanding the diverse microbial communities it harbors has been a significant task. Traditional methods fail to capture the full spectrum of ...
Cell & Microbiology
Oct 9, 2024
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