Rules of resistance against transgene silencing

Clear rules for engineering transgenes that can be inserted and propagated over multiple generations of nematodes include ways to protect inserted genes from the organism's natural defenses against foreign DNA. Developed ...

Understanding how genetic motifs conduct 'the music of life'

Our genetic codes control not only which proteins our cells produce, but also—to a great extent—in what quantity. This groundbreaking discovery, applicable to all biological life, was recently made by systems biologists ...

Researchers reveal recipe for engineering ribosomes

Ribosomes are complex molecular machines in the cell that catalyze the production of proteins. Ahmed Badran, a Broad Fellow at the Broad Institute of MIT and Harvard, and his lab aim to engineer new kinds of ribosomes that ...

Building a corn cob—cell by cell, gene by gene

Corn hasn't always been the sweet, juicy delight that we know today. And, without adapting to a rapidly changing climate, it is at risk of losing its place as a food staple. Putting together a plant is a genetic puzzle, with ...

Biologists unravel full sequence of DNA repair mechanism

Every living organism has DNA, and every living organism engages in DNA replication, the process by which DNA makes an exact copy of itself during cell division. While it's a tried-and-true process, problems can arise.

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