Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy. Until now, viral systems have been the most effective method for delivering genetic matter but they ...
Bio & Medicine
Feb 14, 2017
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40
Evidence of DNA "scrunching" may one day lead to a new class of drugs against viruses, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, the Georgia Institute of Technology, ...
Biochemistry
Jun 8, 2016
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7
Researchers have recreated the evolutionary lineage of adeno-associated viruses (AAVs) to reconstruct an ancient viral particle that is highly effective at delivering gene therapies targeting the liver, muscle, and retina. ...
Cell & Microbiology
Jul 30, 2015
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107
(Phys.org) —By loading any specific protein and nucleic acid into an icosahedral phage T4 capsid-based nanoparticle, the resulting cell delivery vehicle's ligands can bind to the surface of specific target tissues to deliver ...
Researchers at the Polytechnic Institute of New York University (NYU-Poly) and the NYU College of Dentistry (NYUCD) have developed a carrier in their lab that is five times more efficient in delivering DNA into cells than ...
Biochemistry
Dec 16, 2013
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0
Rice University researchers are making strides toward a set of rules to custom-design Lego-like viral capsid proteins for gene therapy.
Biotechnology
Aug 12, 2013
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Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental ...
Mathematics
May 31, 2013
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0
A long-forgotten candidate for antiviral therapy is undergoing a renaissance: Since the 1970s, the small molecule CMA has been considered a potent agent against viral infections, yet it was never approved for clinical use. ...
Cell & Microbiology
Apr 19, 2013
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0
Researchers from Johns Hopkins and Northwestern universities have discovered how to control the shape of nanoparticles that move DNA through the body and have shown that the shapes of these carriers may make a big difference ...
Bio & Medicine
Oct 12, 2012
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0
Researchers report that myxoma – a pox virus that afflicts rabbits but not humans, dogs or any other vertebrates so far studied – infects several different types of canine cancer cells in cell culture while sparing healthy ...
Plants & Animals
Sep 10, 2012
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