Researchers engineer a hybrid five times more effective in delivering genetic material into cells
Researchers at the Polytechnic Institute of New York University (NYU-Poly) and the NYU College of Dentistry (NYUCD) have developed a carrier in their lab that is five times more efficient in delivering DNA into cells than ...
Writing rules for gene-therapy vectors: Researchers compute, then combine benign viruses to fight disease
Rice University researchers are making strides toward a set of rules to custom-design Lego-like viral capsid proteins for gene therapy.
Surges in latent infections: Mathematical analysis of viral blips
Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard ...
From blank round to a potently active substance?
A long-forgotten candidate for antiviral therapy is undergoing a renaissance: Since the 1970s, the small molecule CMA has been considered a potent agent against viral infections, yet it was never approved ...
Scientists discover that shape matters in DNA nanoparticle therapy
Researchers from Johns Hopkins and Northwestern universities have discovered how to control the shape of nanoparticles that move DNA through the body and have shown that the shapes of these carriers may make ...
Scientists put a pox on dog cancer
Researchers report that myxoma – a pox virus that afflicts rabbits but not humans, dogs or any other vertebrates so far studied – infects several different types of canine cancer cells in cell culture while sparing healthy ...
Viruses with integrated gene switch
Scientists of the German Cancer Research Center have developed "RNA switches" which allow them to specifically turn on and off genes in viruses. This will help to enhance regulation of gene therapy and viral therapy of cancer.
New complex offers potentially safer alternative for gene therapy delivery
Spontaneous ordering of DNA fragments in a special matrix holds the key to creating non-toxic gene therapy delivery vectors, according to a study recently published in the European Physical Journal E.
Kidney gene implicated in increased heart failure risk
(PhysOrg.com) -- Scientists have identified the first DNA sequence variant common in the population that is not only associated with an increased risk of heart failure, but appears to play a role in causing it.
Use the common cold virus to target and disrupt cancer cells?
A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted ...
Study finds early HAART during TB treatment boosts survival rate in co-infected people
A clinical trial in Cambodia has found it possible to prolong the survival of untreated HIV-infected adults with very weak immune systems and newly diagnosed tuberculosis (TB) by starting anti-HIV therapy two weeks after ...
Scientists design new delivery device for gene therapy
Scientists have designed a nanoparticle that appears to effectively deliver genetic material into cells with minimal toxic effects.
Gene therapy sets stage for new treatments for inherited blindness, researchers say
Veterinary vision scientists at the University of Pennsylvania have safely and successfully used a viral vector in targeting a class of photoreceptors of the retina called rods, a critical first step in developing ...
Researchers identify key molecular step to fighting off viruses
UT Southwestern Medical Center researchers have determined how a protein that normally latches onto molecules inside cells and marks them for destruction also gives life to the body's immune response against viruses.