Disruption of certain DNA structures—called topologically associating domains, or TADs—is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps ...
Biotechnology
Dec 17, 2019
0
215
Hibernation is one of nature's strangest quirks, inducing bears and other mammals to pack on massive weight—amounts that would be unhealthy for humans—so they can survive months of slumber. Yet when these animals reemerge, ...
Biotechnology
Nov 26, 2019
0
37
How, where and when genes are expressed determine individual phenotypes. If gene expression is controlled by many regulatory elements, what, ultimately, controls them? And how does genetic variation affect them? The SysGenetiX ...
Molecular & Computational biology
May 2, 2019
0
91
Snakes and lizards are reptiles that belong to the order Squamata. They share several traits but differ in one obvious respect: Snakes do not have limbs. The two suborders diverged more than 100 million years ago. Identification ...
Evolution
Feb 7, 2019
11
273
It was long thought that DNA, together with the genes encoded in it, determined genetic destiny. But equally important is coordinating when genes are turned on and off. In fact, the regulation of gene expression defines life ...
Evolution
Sep 11, 2018
1
15
The sites where transcription factors bind within regulatory DNA fall into six distinct patterns that overlap with the factors' functions, Broad scientists find, helping advance a goal of regulatory genomics.
Cell & Microbiology
Jul 11, 2018
0
7
In recent years, it has become evident that the spatial organisation of the genome is key for its function. This depends on a number of factors, including the cohesin protein complex. This essential complex is present in ...
Cell & Microbiology
Jun 5, 2018
0
62
A team of biologists and computer scientists has adopted a time-based machine-learning approach to deduce the temporal logic of nitrogen signaling in plants from genome-wide expression data. The work potentially offers new ...
Biotechnology
May 14, 2018
0
80
A molecular "motor" that organizes the genome into distinct neighborhoods by forming loops of DNA has been characterized by researchers at MIT and the Pasteur Institute in France.
Cell & Microbiology
Sep 29, 2017
1
16
Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any ...
Cell & Microbiology
Sep 14, 2017
0
342
