Proteins are like machines. For some diseases, it can be useful to turn these machine off or on when they are too active or not active enough. One way to control switching in a protein, such as a nuclear receptor, is to put ...
Molecular & Computational biology
Jun 1, 2022
0
5
A collaborative effort has revealed a new type of triterpene, a group of organic compounds which are an important source of many medicines. Until now, all triterpenes were believed to be derived from squalene, itself a type ...
Biochemistry
Jun 1, 2022
0
140
Most people carry the fungus Candida albicans on their bodies without it causing many problems. However, a systemic infection with this fungus is dangerous and difficult to treat. Few antimicrobials are effective, and drug ...
Cell & Microbiology
May 25, 2022
0
105
FMI researchers have identified a synthetic protein that dampens the activity of a cellular pathway involved in viral infection. The findings could help to develop drugs that combat viruses such as influenza A and Zika.
Cell & Microbiology
May 11, 2022
0
117
Scientists have developed a new technique to accelerate the discovery of cancer-fighting drugs. The technique identifies molecules that can shut down dangerous proteins before they wreak disease-triggering havoc, by blocking ...
Biochemistry
Apr 7, 2022
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85
The number of potential therapeutic targets on the surfaces of human proteins is much greater than previously thought, according to the findings of a new study in the journal Nature.
Molecular & Computational biology
Apr 6, 2022
1
216
A team of scientists has created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable ...
Biochemistry
Mar 25, 2022
0
24
In a structural analysis that could help inform efforts to develop new drugs for treating a myriad of diseases, RIKEN biologists have shed light on how the interaction between key signaling proteins and their regulatory partners ...
Cell & Microbiology
Mar 15, 2022
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37
The amount of structural data on protein drug targets continues to grow. However, successfully mining this data to form testable hypotheses that drive drug discovery can prove challenging. Selectivity for the target protein ...
Biochemistry
Mar 2, 2022
0
11
The job of a protein hub inside the nucleus of a cell is similar to that of a chef in a kitchen. Both need to manage multiple tasks efficiently for a successful outcome. For the chef, if they spend too much time chopping ...
Cell & Microbiology
Feb 23, 2022
0
34
