Bioinformaticians examine new genes the moment they are born

Accumulating evidence suggests that new genes can arise spontaneously from previously non-coding DNA instead of through the gradual mutation of established genes. Bioinformaticians at the University of Münster (Germany) ...

The underestimated mutation potential of retrogenes

Genetic information is stored in DNA and transcribed as mRNA. The mRNA is usually translated into proteins. However, it has long been known that mRNA can also be reverse transcribed to DNA and integrated back into the genome. ...

Bread mould avoids infection by mutating its own DNA

Whilst most organisms try to stop their DNA from mutating, scientists from the UK and China have discovered that a common fungus found on bread actively mutates its own DNA as a way of fighting virus-like infections.

Scientists optimize prime editing for rice and wheat

Many genetic and breeding studies have shown that point mutations and indels (insertions and deletions) can alter elite traits in crop plants. Although nuclease-initiated homology-directed repair (HDR) can generate such changes, ...

Researchers clarify bacterial resistance

Just like plants and animals, bacteria have a range of defence mechanisms against viruses and other threats. Dutch researchers at the Wageningen Laboratory for Microbiology and their American and Russian colleagues have largely ...

Uncovering the secret of insulin growth factor ternary complex

Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses and children, but also body maintenance and metabolism in adults. IGF regulates cell proliferation, differentiation, and survival by ...

Split gene-editing tool offers greater precision

To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.

Non-independent mutations present new path to evolutionary success

Mutations of DNA that lead to one base being replaced by another don't have to happen as single, independent events in humans and other eukaryotes, a group of Indiana University Bloomington biologists has learned after surveying ...

DNA base editing induces substantial off-target RNA mutations

In a study published in Nature on June 10, researchers from Dr. Yang Hui's Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational ...

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