Scientists from the Florida campus of The Scripps Research Institute (TSRI) have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.
Biochemistry
Jan 13, 2014
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0
The bark of the Galbulimima belgraveana tree, found only in remote rainforests of Papua New Guinea and northern Australia, has long been used by indigenous people for both healing and ceremony. A tea brewed from the bark ...
Biochemistry
May 13, 2022
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218
(Phys.org) —Almost every biological process involves sensing the presence of a certain chemical. Finely tuned over millions of years of evolution, the body's different receptors are shaped to accept certain target chemicals. ...
Bio & Medicine
May 6, 2014
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0
Pain, especially chronic pain, is a common neurological phenomenon. The most common chronic pain conditions include low back pain, arthritis pain, migraine and cancer pain—all of which seriously affect people's physical ...
Biochemistry
Nov 16, 2022
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94
Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...
Biochemistry
Jun 22, 2018
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74
Using a newly developed X-ray source, scientists have revealed how a new type of pain-relievers works - bonding to the same neuroreceptors that morphine does, but without the accompanying physical dependence.
Biochemistry
Feb 18, 2015
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39
"Pain begone!" In order to send out this signal, the human body produces tiny messenger molecules that dock to certain receptors. Using traditional biochemical methods, this interaction between the messengers, so-called enkephalins, ...
Biochemistry
Jul 9, 2013
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0
Readers of the top-ranked scientific journals Science and Nature might have noticed a recent wave of articles, most recently in the July 13, 2012 issue of Science, with deep importance for biology and medicine. These papers, ...
Cell & Microbiology
Jul 12, 2012
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0
Drug discovery may bring to mind images of white lab coats and pipettes, but when Henry Lin, PhD, recently set out to find a better opioid with fewer side effects, his first step was to fire up the computers.
Biochemistry
Apr 6, 2017
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9
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
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20
