News tagged with nucleosomes

Unspooling DNA from nucleosomal disks

The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...

May 23, 2013
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How proteins read meta DNA code

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read ...

Mar 19, 2013
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Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms ...

Oct 05, 2012
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New type of extra-chromosomal DNA discovered

(PhysOrg.com) -- A team of scientists from the University of Virginia and University of North Carolina in the US have discovered a previously unidentified type of small circular DNA molecule occurring outside ...

Mar 09, 2012 report
4.8 / 5 (24) 9 | with audio podcast

A foot in the door to genetic information

In the cell nucleus, DNA wraps around what are called histone proteins, forming regularly spaced spherical bodies called nucleosomes. Thus, large portions of the genetic material are inaccessible to the gene reading machinery. ...

Mar 07, 2012
4.3 / 5 (3) 0 | with audio podcast

Elusive Z- DNA found on nucleosomes

New research published in BioMed Central's open access journal Cell & Bioscience is the first to show that left-handed Z-DNA, normally only found at sites where DNA is being copied, can also form on nucleosomes.

Jan 20, 2012
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