Uncovering hidden mitochondrial mutations in single cells

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies ...

Conservation of Nara Park deer results in unique genetic lineage

The existing wildlife of a region is heavily shaped over generations by environmental factors and human activity. Activities like urbanization and hunting are known to reduce wildlife populations. However, some cultural or ...

First mouse model with mitochondrial tRNALeu mutation developed

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial ...

A new era of mitochondrial genome editing has begun

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED. TALEDs are base editors ...

Are egg cells in aging primates protected from mutations?

New mutations occur at increasing rates in the mitochondrial genomes of developing egg cells in aging rhesus monkeys, but the increases appear to plateau at a certain age and are not as large as those seen in non-reproductive ...

Gene triggers male sterility in tomato plants

Despite its culinary versatility, the humble tomato isn't known for being mysterious. But there's still plenty to learn: researchers from Japan have discovered the gene underlying male sterility in these plants.

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