PIM kinases are enzymes that are evolutionarily well conserved in both humans and nematodes. Led by Dr. Päivi Koskinen, a research group from the Department of Biology of the University of Turku in Finland has previously ...
Plants & Animals
Aug 27, 2019
0
5
The activation of mTor complex 1 in the cell is central to many vital processes in the body such as cell growth and metabolism. Overactivity of this signaling pathway can result in diseases such as in diabetic insulin resistance ...
Cell & Microbiology
Aug 27, 2019
0
18
"Resurrecting" the ancestors of key proteins yields evolutionary insights into their role in human cells and in most cancers, a new study finds.
Molecular & Computational biology
Aug 13, 2019
0
58
An international research team has revealed a novel mechanism for the perception of endogenous peptides by a plant receptor. The discovery of this activation mechanism sets a new paradigm for how plants react to internal ...
Plants & Animals
Jul 11, 2019
0
20
What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal ...
Bio & Medicine
Apr 17, 2019
0
25
G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
Biochemistry
Apr 4, 2019
0
7
The unicellular parasite that causes sleeping sickness differs from other eukaryotes in the mode of regulation of an essential cellular signaling pathway. This provides a promising point of attack for drug development.
Cell & Microbiology
Apr 3, 2019
0
6
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
0
186
The cytoskeleton is a structure that not only helps cells maintain their shape and internal organisation, but also enables them to perform functions like movement and migration to sites far from the place where they originated. ...
Cell & Microbiology
Mar 12, 2019
0
47
