Junk DNA in birds may hold key to safe, efficient gene therapy

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job of knocking out genes to cure hereditary disease. But it's still not possible to insert whole genes ...

'Genomic time machine' reveals secrets of our DNA

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within the genome, known as "transposable ...

How HIV smuggles its genetic material into the cell nucleus

Each year, about 1 million individuals worldwide become infected with HIV, the virus that causes AIDS. To replicate and spread the infection, the virus must smuggle its genetic material into the cell nucleus and integrate ...

CRISPR off-switches: A path towards safer genome engineering?

Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells. In fact, the first CRISPR-based therapeutic was recently approved ...

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