New way to target 'undruggable' molecules involved in cancer

For decades, cancer researchers have longed for a way to target a set of proteins called transcription factors. While we've long known that tumors use these proteins to grow out of control, their unique configurations meant ...

The force to shape an organ

Carnegie Mellon University professor of biomedical engineering and materials science and engineering Adam Feinberg, along with postdoctoral fellow Dan Shiwarski and graduate student Joshua Tashman, have created a novel biosensor ...

MIB2 enhances inflammation by degradation of CYLD

A team of researchers at Ehime University revealed that E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. This finding was published on Sept. 20 in the Journal of Biological Chemistry.

Understanding the growth of coral reefs

Determining the growth dynamics of Red Sea coral reefs has enabled researchers to establish a baseline to assess the effects of environmental change.

How a shape-shifting receptor influences cell growth

Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment. MIT chemists have now discovered how one of these receptors changes its shape when it binds to ...

Alternative to fishing – cell-based fish from the bioreactor

Already about 90 percent of all fish stocks are considered maximally exploited or overfished, according to the United Nations Food and Agriculture Organization. But as the world's population continues to grow, more and more ...

Time (and PPAR-beta/delta) heals all wounds

Mammalian skin requires constant maintenance, but how do skin cells know when to proliferate and at what rate? In the March 23, 2009 issue of the Journal of Cell Biology, Nguan Soon Tan and colleagues reveal that skin fibroblasts ...

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