A mitochondria-targeted fluorescent probe for cisplatin
NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell models.
NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell models.
Biochemistry
Jun 10, 2021
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In the time it takes for an Amazon Prime delivery to arrive, cells damaged by chemotherapy can almost completely fix their most important DNA. That is the case in the livers of mice at least, according to a new study.
Biochemistry
Jul 1, 2019
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(Phys.org) —Scientists at the U.S. Department of Energy's Argonne National Laboratory have added a new weapon to oncologists' arsenal of anti-cancer therapies.
Bio & Medicine
Aug 14, 2014
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(Phys.org) —University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.
Bio & Medicine
Jul 7, 2014
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First approved by the FDA in the 1970s, the chemotherapy drug cisplatin and its relative carboplatin remain mainstays of treatment for lung, head and neck, testicular and ovarian cancer. However, cisplatin's use is limited ...
Biochemistry
May 5, 2014
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(Phys.org)—Metals such as copper, zinc, and iron are important nutrients to all life. The special properties of these elements that make them so useful in technologies including batteries and catalysts – for example, ...
Biochemistry
Sep 10, 2012
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Researchers at Brigham and Women's Hospital (BWH) are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment.
Bio & Medicine
Jul 10, 2012
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A long-used anti-cancer drug could be a starting point to develop new treatments for the incurable nerve disease known as Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS), scientists are reporting. Their research ...
Biochemistry
Jun 13, 2012
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(Phys.org) -- For more than three decades scientists have been investigating magnetic nanoparticles as a method of drug delivery. Now by combining three metals - iron, gold and platinum - pharmacists at the University of ...
Bio & Medicine
May 31, 2012
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(Phys.org) -- A team of University of California, San Diego researchers has made new discoveries about a copper-transporting protein in the membranes of human cells that drug-discovery scientists can co-opt for the development ...
Biochemistry
May 17, 2012
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Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
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