NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell models.
Biochemistry
Jun 10, 2021
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(Phys.org) —Scientists at the U.S. Department of Energy's Argonne National Laboratory have added a new weapon to oncologists' arsenal of anti-cancer therapies.
Bio & Medicine
Aug 14, 2014
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(Phys.org) —University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells.
Bio & Medicine
Jul 7, 2014
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0
First approved by the FDA in the 1970s, the chemotherapy drug cisplatin and its relative carboplatin remain mainstays of treatment for lung, head and neck, testicular and ovarian cancer. However, cisplatin's use is limited ...
Biochemistry
May 5, 2014
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(Phys.org)—Metals such as copper, zinc, and iron are important nutrients to all life. The special properties of these elements that make them so useful in technologies including batteries and catalysts – for example, ...
Biochemistry
Sep 10, 2012
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Researchers at Brigham and Women's Hospital (BWH) are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment.
Bio & Medicine
Jul 10, 2012
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(Phys.org) -- A team of University of California, San Diego researchers has made new discoveries about a copper-transporting protein in the membranes of human cells that drug-discovery scientists can co-opt for the development ...
Biochemistry
May 17, 2012
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0
(PhysOrg.com) -- Gold nanoparticles can be used as delivery vehicles for platinum anticancer drugs, improving targeting and uptake into cells, according to research published in this month's edition of the international journal ...
Bio & Medicine
Mar 21, 2012
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An anti-cancer drug used extensively in chemotherapy binds pervasively to RNA -- up to 20-fold more than it does to DNA, a surprise finding that suggests new targeting approaches might be useful, according to University of ...
Biochemistry
Nov 21, 2011
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(PhysOrg.com) -- An ideal treatment for lung cancer would be one that could be inhaled deep into lung tissue where it would deliver tumor-killing agents that would then largely stay in the lungs, avoiding the toxicities that ...
Bio & Medicine
Nov 21, 2011
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Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
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