The transporter protein ABCG2 belongs to the ATP-binding-cassette (ABC) family. The protein is expressed in the plasma membranes of cells within a variety of tissues and tissue barriers, including the blood-brain, blood-testes ...
A new piece of a difficult puzzle—the nature of memory—fell into place this week with a hint at how brain cells change structure when they learn something.
Biochemistry
Aug 26, 2019
0
223
People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn't been entirely clear how we do ...
Biochemistry
Feb 7, 2019
0
75
To date, much has been stated about the promise of quantum computing for myriad of applications but there have been few examples of a quantum advantage for real-world problems of practical interest. This might change with ...
Quantum Physics
Feb 27, 2018
0
529
MIT researchers have shown that they can turn genes on or off inside yeast and human cells by controlling when DNA is copied into messenger RNA—an advance that could allow scientists to better understand the function of ...
Biotechnology
Sep 3, 2013
0
0
A team of researchers working at Germany's Technische Universität Braunschweig has succeeded in using a previously known DNA origami construction technique to build a nanoantenna with a docking site. First published in the ...
Scientists at the University of Liverpool have shed new light on how diving mammals, such as the sperm whale, have evolved to survive for long periods underwater without breathing.
Plants & Animals
Jun 13, 2013
0
0
Berkeley Lab and UC Berkeley researchers have discovered that the transcription factor protein TFIID coexists in two distinct structural states, a key to genetic expression and TFIID's ability to initiate the process by which ...
Cell & Microbiology
Jan 17, 2013
0
0
A research team led by biogeochemists at the University of California, Riverside has tested a popular hypothesis in paleo-ocean chemistry, and proved it false.
Cell & Microbiology
Dec 23, 2012
15
0
Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus and one ...
Cell & Microbiology
Nov 21, 2011
0
0
Carrier proteins are proteins that transport a specific substance or group of substances through intracellular compartments or in extracellular fluids (e.g. in the blood) or else across the cell membrane. Some of the carriers are water-soluble proteins that may or may not interact with biological membranes, such as some transporters of small hydrophobic molecules, whereas others are integral transmembrane proteins.
Carrier proteins transport substances out of or into the cell by facilitated diffusion and active transport. Each carrier protein is designed to recognize only one substance or one group of very similar substances. The molecule or ion to be transported (the substrate) must first bind at a binding site at the carrier molecule, with a certain binding affinity. Following binding, and while the binding site is facing, say, outwards, the carrier will capture or occlude (take in and retain) the substrate within its molecular structure and cause an internal translocation, so that it now faces the other side of the membrane. The substrate is finally released at that site, according to its binding affinity there. All steps are reversible.
For example:
This text uses material from Wikipedia, licensed under CC BY-SA
