Stem cells alleviate tumor treatment side effects

Nov 17, 2009 by Jennifer Fitzenberger
Charles Limoli and colleagues found that human embryonic stem cells can alleviate the side effects of brain tumor radiation in rats. Image: Steve Zylius

(PhysOrg.com) -- Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new UC Irvine study.

Human could help people with learning and memory deficits after for brain tumors, suggests a new UC Irvine study.
Research with rats found that transplanted stem cells restored learning and memory to normal levels four months after radiotherapy. In contrast, irradiated rats that didn't receive stem cells experienced a more than 50 percent drop in cognitive function.

"Our findings provide the first evidence that such cells can be used to ameliorate radiation-induced damage of healthy tissue in the brain," says Charles Limoli, UCI associate professor and senior author of the study, appearing online the week of Nov. 9 in the .

Radiotherapy for is limited by how well the surrounding tissue tolerates the treatment. In receiving radiation at levels needed to treat tumors, patients suffer varying degrees of learning and memory impairment that can affect their quality of life.

"It's a progressive, debilitating side effect of cranial irradiation," Limoli says. "Any treatments showing promise at reversing this are worthy of pursuit."

In the UCI study, stem cells were transplanted into the heads of rats that had undergone radiation treatment. They migrated to a brain region known to support the growth of neurons, scientists observed, and developed into new brain cells.

Work is under way to determine how the transplanted stem cells improved cognition: Did they integrate into healthy tissue or did they help repair and support existing brain cells?

Says Limoli: "With further research, may one day be used to manage a variety of adverse conditions associated with radiotherapy."

In addition to Limoli, UCI scientists Munjal Acharya, Lori-Ann Christie, Mary Lan, Peter Donovan and Carl Cotman worked on this study, in collaboration with John Fike of UC San Francisco. The UCI researchers are from the departments of radiation oncology, biological chemistry, and developmental & cell biology; the Institute for Impairments and Neurological Disorders, or UCI MIND; and the Sue & Bill Gross Stem Cell Research Center.

Provided by UC Irvine

Explore further: Attacking persister cells that are responsible for making bacteria resistant to new drugs

add to favorites email to friend print save as pdf

Related Stories

New stem cell technique improves genetic alteration

Mar 07, 2008

UC Irvine researchers have discovered a dramatically improved method for genetically manipulating human embryonic stem cells, making it easier for scientists to study and potentially treat thousands of disorders ranging from ...

Recommended for you

Driving cancer cells to suicide

6 hours ago

Ludwig Maximilian University of Munich researchers report that a new class of chemical compounds makes cancer cells more sensitive to chemotherapeutic drugs. They have also pinpointed the relevant target ...

User comments : 0