NIST focuses on testing standards to support lab on a chip commercialization

Aug 09, 2012
This is a microfluidic lab on a chip device sitting on a polystyrene dish. Stainless steel needles inserted into the apparatus serve as access points for fluids into small channels within it. Credit: Gregory A. Cooksey/NIST

Lab on a chip (LOC) devices -- microchip-size systems that can prepare and analyze tiny fluid samples with volumes ranging from a few microliters (millionth of a liter) to sub-nanoliters (less than a billionth of a liter) -- are envisioned to one day revolutionize how laboratory tasks such as diagnosing diseases and investigating forensic evidence are performed. However, a recent paper* from the National Institute of Standards and Technology (NIST) argues that before LOC technology can be fully commercialized, testing standards need to be developed and implemented.

"A testing standard," explains NIST physical scientist and paper author Samuel Stavis, "defines the procedures used to determine if a lab on a device, and the materials from which it is made, conform to specifications." and measurement methods, Stavis writes, will enable MEMS () LOC manufacturers at all stages of production—from processing of raw materials to final rollout of products—to accurately determine important physical characteristics of LOC devices such as dimensions, electrical surface properties, and fluid flow rates and temperatures.

To make his case for testing standards, Stavis focuses on autofluorescence, the background fluorescent glow of an LOC device that can interfere with the analysis of a sample. Stavis states that multiple factors must be considered in the development of a testing standard for autofluorescence, including: the materials used in the device, the measurement methods used to test the device and how the measurements are interpreted. "All of these factors must be rigorously controlled for, or appropriately excluded from, a meaningful measurement of autofluorescence," Stavis writes.

Quality control during LOC device manufacturing, Stavis says, may require different tests of autofluorescence throughout the process. "There may be one measure of autofluorescence from the block of plastic that is the base material for a chip, another once the block has been fashioned into the substrate in which the functional components are embedded, and yet another as the final device is completed," Stavis says. "To manufacture lab on a chip devices with reliably low autofluorescence, accurate measurements may be needed at each stage."

Stavis also emphasizes that it is important not to confuse testing standards with product standards, and to understand how the former facilitates the latter. "A product standard specifies the technical requirements for a lab on a chip to be rated as top quality," he says. "A testing standard is needed to measure those specifications, as well as to make fair comparisons between competing products."

Explore further: Researchers use passive UHF RFID tags to detect how people interact with objects

Related Stories

Three new standards for MEMS devices

Jul 16, 2004

Researchers at the National Institute of Standards and Technology (NIST), along with their colleagues at several companies, are completing experiments that validate new standards aimed at improving emerging new microelectromechanical ...

'Micro-rack' measures cell mechanical properties

Mar 02, 2007

Researchers at the National Institute of Standards and Technology have developed a microelectromechanical system (MEMS) cell-stretcher that can measure the mechanical properties of a living cell, such as its ...

Recommended for you

Intellectual property in 3D printing

Apr 16, 2015

The implications of intellectual property in 3D printing have been outlined in two documents created for the UK government by Bournemouth University's Dinusha Mendis and Davide Secchi, and Phil Reeves of Econolyst Ltd.

World-record electric motor for aircraft

Apr 16, 2015

Siemens researchers have developed a new type of electric motor that, with a weight of just 50 kilograms, delivers a continuous output of about 260 kilowatts – five times more than comparable drive systems. ...

Space open for business, says Electron launch system CEO

Apr 15, 2015

Space, like business, is all about time and money, said Peter Beck, CEO of Rocket Lab, a US company with a New Zealand subsidiary. The problem, he added, is that, in cost and time, space has remained an incredibly ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.