Repeat act: Parallel selection tweaks many of the same genes to make big and heavy mice

May 08, 2012
One giant mouse weighs more than six 'mini-mice' of the same age. The biggest mice in the world evolved through targeted breeding over many generations. Scientists can use these animals to identify the genes responsible for body growth. Credit: Lutz Bunger, University of Edinburgh

Organisms are adapted to their environment through their individual characteristics, like body size and body weight. Such complex traits are usually controlled by many genes. As a result, individuals show tremendous variations and can also show subtle gradations. Researchers from the Max Planck Institute for Evolutionary Biology in Plön have now investigated how evolution alters such traits through selection. To do this, they examined the genomes of mouse lines that were selected independently of each other for extreme body size. They discovered that a number of genomic regions, or loci, have undergone changes in genes that underlie this genetically complex characteristic. They also discovered many new genes that play a role in the regulation of body weight, which can lead to obesity.

The Plön-based researchers obtained mouse lines that have been specifically selected for extreme for 25 years. The mice, which have been bred for over 150 generations, belong to seven different strains and now weigh two to four times more than mice of normal weight. The Max Planck scientists were able to identify a total of 67 loci on the genome that had changed in the heavy mice. The different strains have become so similar in these regions as a result of the extreme artificial selection pressure, that the genomes of the heavier but unrelated animals were more similar at these loci than with their closely related sibling mouse strains of those with normal weight. This clearly indicates that these loci are involved in the regulation of body weight.

The discovered loci regulate, among other things, energy balance, metabolic processes and growth. The Gpr133 gene, which is expressed in the adrenal gland, is a novel gene and presumably controls body weight through the release of hormones. The second identified gene, Gpr10, which is active in the hypothalamus in the brain, was found to influence appetite and metabolic rates. Accordingly, the team has also identified for the regulation of fat cells and for taste and olfactory perception that can affect body weight. Moreover, many of the regions discovered coincide with loci on the human genome that influence body weight. "These genes probably also determine body weight in humans, because size and body weight are such tightly linked processes. This evolutionary connection serves as a nice confirmation," says Frank Chan from the Max Planck Institute for .

Interestingly, the genome of mouse populations living in the wild on remote islands, shaped by natural selection, have also changed in similar ways to the animals bred in the laboratory. For example, on the Faroe Islands and St Kilda off the coast of Scotland, mice populations have evolved to be among the largest mice in the world. The researchers have found that island mice retained little variation specifically at the same genomic loci that changed in the heavy laboratory-bred animal strains. These telltale signs suggest that artificial selection in the laboratory changes the same loci in the genome as natural selection.

Thus, when complex characteristics must adapt to altered environmental conditions, selection affects many responsible genes simultaneously. These then change in parallel and contribute to varying extents to the organism's capacity for adaptation. In this way, the genetic basis of complex traits can be decoded through parallel selection.

Explore further: Chickens to chili peppers: Scientists search for the first genetic engineers

More information: Chan, Y. F. et al. Parallel selection mapping using artificially selected mice reveals body weight control loci. Current Biology: Volume 22, Issue 9, 8 May 2012, Page 794, doi:10.1016/j.cub.2012.03.011

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flicktheswitch
not rated yet May 09, 2012
In before Kevinrtrs suggests "natural selection pressure" and "evolution" are ridiculous concepts and all this strange mutation could only have ever come about in a lab...

Also: Very impressed by this drive to use forced selection pressure to confirm data from previous experiments that simply looked at relevant genes via comparison and deduction, and potentially open up new lines of inquiry.

Would totally want a Mega Mouse as a pet. ;)

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