Astrobiology meets cancer research

Feb 08, 2011
Tumors and their kin.

(PhysOrg.com) -- In an interplanetary meeting of the minds, astrobiologists and oncologists have worked together to provide new insights into the origins of cancer, which remains a major killer despite the best efforts of medical science to treat and eradicate it.

These two groups of scientists approach science from quite different perspectives. Oncologists, who focus on cancer from a biological perspective, look at how we can prevent and treat cancer’s development. Astrobiologists, on the other hand, spend their time pondering the question ‘are we alone?’ combining their training in physics with research into the origins of life on our planet.

Working with the United States’ National Institutes of Health (NIH), specialists from the two fields have come up with some important new understandings of what cancer is. The results of the cooperative effort are published in today’s issue of Physical Biology.

Dr. Charles Lineweaver from the Research School of Astronomy and Astrophysics and the Research School of Earth Sciences at ANU said the new model, developed with Professor Paul Davies at Arizona State University, depicts cancer as an atavism – an evolutionary throwback.

“Unlike bacteria and viruses, cancer has not developed the capacity to evolve into new forms. In fact, cancer is better understood as the reversion of cells to the way they behaved a little over one billion years ago, when humans were nothing more than loose-knit colonies of only partially differentiated cells.

“We think that the tumors that develop in cancer patients today take the same form as these simple cellular structures did more than a billion years ago,” he said.

Looking at life from the big picture point of view, outside the oncologists’ laboratories, reminds scientists that cancer does not invade the human body, but is in fact already built into our DNA.

“Our new model should give new hope,” said Dr. Lineweaver. “It suggests that cancer is a limited and ultimately predictable adversary.

is not going anywhere evolutionarily; it simply starts up in a new patient similar to the way it started in the previous one.”

Explore further: Four billion-year-old chemistry in cells today

More information: The paper, ‘Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors’ appears in the current edition of Physical Biology. A copy of the paper is available online: bit.ly/gMnH0H

Provided by Australian National University

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