UNC team discovers promising target for new pancreatic cancer treatments

Nov 05, 2010

One of the most frustrating problems faced by doctors who treat pancreatic cancer is the lack of effective therapeutic options. More than 38,000 people in the United States die of the disease each year, and new drugs and treatments are desperately needed.

For almost three decades, scientists and physicians have known that a gene called the KRAS is mutated in virtually all pancreatic cancers, making it an important target for scientists looking for a way to stop the growth of tumors. The problem is that the KRAS gene triggers in numerous ways, through multiple cell signaling pathways, and scientists have had difficulty determining which one will be the most promising to block – an important first step in designing a drug for use in patients.

In a paper published today in the Journal of Biological Chemistry, a team from UNC Lineberger Comprehensive Cancer Center has narrowed the focus of this scientific quest to a protein called RGL2.

According to Channing Der, PhD, who led the research, "The pathway we talk about this paper is one we have investigating for more than five years. We think it is an attractive target for achieving what has, to date, been impossible: making a KRAS-blocking drug."

Der, who is a distinguished professor of pharmacology and UNC Lineberger member, says, "We are particularly optimistic about RGL2 because we know that this protein is a critical component of KRAS signaling to another class of proteins called Ral GTPases, which are essential for the growth of almost all pancreatic tumors."

Working with Jen Jen Yeh, MD, assistant professor of surgery, Sharon Campbell, PhD, professor of biochemistry and biophysics, Der and his laboratory team were able to demonstrate that RGL2 is overexpressed – not only in pancreatic tumor cells grown in the laboratory but also in tissue taken from pancreatic cancer patients.

According to Der, "Many ideas work in the artificial environment of cell culture but not in real cancer patients. Our work with actual pancreatic tumor tissue makes us optimistic that our new understanding of this pathway can lead to a therapeutic impact for the cancer patient."

Explore further: New tool identifies therapeutic proteins in a 'snap'

add to favorites email to friend print save as pdf

Related Stories

Zinc transporters regulate pancreatic cancer

Nov 12, 2007

Zinc, an important trace element for healthy growth and development, can be related to pancreatic cancer. Too much ZIP4, a molecule that enables the transport of zinc into cells, promotes the growth and spread of pancreatic ...

Recommended for you

New tool identifies therapeutic proteins in a 'snap'

1 hour ago

(Phys.org) —In human and bacterial cells, glycosylation – the chemical process of attaching complex sugar molecules to proteins – is as fundamental as it gets, affecting every biological mechanism from cell signaling ...

Treating pain by blocking the 'chili-pepper receptor'

22 hours ago

Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others. Scientists exploring the chili pepper's effect are using their findings to develop a new drug ...

Moving single cells around—accurately and cheaply

Aug 19, 2014

Scientists at the Houston Methodist Research Institute have figured out how to pick up and transfer single cells using a pipette—a common laboratory tool that's been tweaked slightly. They describe this ...

The difficult question of Clostridium difficile

Aug 19, 2014

The bacterium Clostridium difficile causes antibiotic-related diarrhoea and is a growing problem in the hospital environment and elsewhere in the community. Understanding how the microbe colonises the hu ...

User comments : 0