Developing new methods for targeted protein degradation

Northwestern Medicine scientists have developed a new, more precise method to target proteins implicated in certain types of cancer, according to a study published in Nature Chemical Biology.

Understanding the role of RNA methylation in cancer

RNA modification could serve as a therapeutic target for certain types of cancer, according to a new study published in Molecular Cell, which sheds new light on the complex process underlying RNA transcription.

Study finds ways to enhance transcription factor activity

Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's ...

Researchers capture never-before-seen view of gene transcription

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription ...

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