Novel sex-determination mechanism revealed in mammals

In mammals, the distinction between male and female at the chromosomal level is due to the X and Y chromosomes. Typically, females have two X chromosomes (XX) while males have an X and a Y chromosome (XY). The Sry gene on ...

Holographic histopathology enables fast, precise diagnostics

Histology is the study of biological tissues at a microscopic level. Also called microscopic anatomy, histology is widely used to provide diagnosis of cancer and other diseases. For example, tissue samples obtained during ...

Understanding the role of RNA methylation in cancer

RNA modification could serve as a therapeutic target for certain types of cancer, according to a new study published in Molecular Cell, which sheds new light on the complex process underlying RNA transcription.

Pioneering automated proteoform imaging

Investigators led by Neil Kelleher, Ph.D., professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, have developed an automated technique for imaging and identifying proteoforms ...

New method melds data to make a 3-D map of cells' activities

Just as it's hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell's environment. To solve that problem, researchers ...

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