Probing how proteins pair up inside cells

Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of which interact with partner ...

Enabling functional genomics studies in individual cells

Although the first complete sequence of the human genome was reported more than 15 years ago, the biological functions of large parts of the genome are not yet known. Scientists working in the field of functional genomics ...

How to target a microbial needle within a community haystack

A team led by researchers at the Max Planck Institute (MPI) for Marine Microbiology has developed, tested and deployed a pipeline to first target cells from communities of uncultivated microbes, and then efficiently retrieve ...

Study advances single-cell transcriptome profiling

With the goal of ensuring that single-cell RNA sequencing makes use of the best possible methods, an international group has benchmarked 13 methods. The group, led by Holger Heyn of the Centro Nacional de Análisis Genómico ...

Chromatin organizes itself into 3-D 'forests' in single cells

A single cell contains the genetic instructions for an entire organism. This genomic information is managed and processed by the complex machinery of chromatin—a mix of DNA and protein within chromosomes whose function ...

Dark centers of chromosomes reveal ancient DNA

Geneticists exploring the dark heart of the human genome have discovered big chunks of Neanderthal and other ancient DNA. The results open new ways to study both how chromosomes behave during cell division and how they have ...

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