Precision genome editing enters the modern era

CRISPR has sparked a renaissance in genome editing. Now, next-generation CRISPR technologies let scientists modify the genome more efficiently and precisely than before. Such tools could one day serve as therapeutics, but ...

First CRISPR single-nucleotide edited transgenic mice

Cystic fibrosis, sickle cell anemia, Huntington's disease and phenylketonuria are all examples of disorders caused by the mutation of a single nucleotide, a building block of DNA. The human DNA consists of approximately 3 ...

What's holding up CRISPR-based cures

The gene-editing tool called CRISPR that can quickly and cleanly remove specific pieces of DNA has revolutionized biotechnology. Many researchers believe the technique could end thousands of ailments. So what's needed to ...

Flowing toward red blood cell breakthroughs

A team of researchers from Brown University and ETH Zurich the Universita da Svizzera Italiana (USI) and Consiglio Nazionale delle Ricerche (CNR) is using America's largest, most powerful supercomputer to help understand ...

A turning point in the physics of blood

Mike Graham knows that fluid dynamics can reveal much about how the flow of blood helps and hinders individual blood cells as they go about their work.

Scientists use light to uncover the cause of sickle cell disease

In sickle cell disease, hemoglobin—the oxygen-carrying component of blood—forms fibers that stiffen red blood cells and cause life-threatening symptoms. Using light-scattering techniques to study the detailed thermodynamics ...

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