Researchers from UCPH have discovered how a mysterious function of the so called minichromosome maintenance (MCM) proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. ...
Cell & Microbiology
Oct 22, 2020
0
134
Transcription factor proteins are the light switches of the human genome. By binding to DNA, they help turn genes 'on' or 'off' and start the important process of copying DNA into an RNA template that acts as a blueprint ...
Biotechnology
Oct 21, 2020
1
86
Loading of replicative helicases onto DNA is a key event during the initiation of chromosomal DNA replication. It takes place at specific chromosomal regions termed origins and is facilitated by the ORC protein complex. By ...
Molecular & Computational biology
Sep 21, 2020
0
74
Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the corona virus manipulates human cells to ensure its own replication. This knowledge will help to develop drugs and vaccines against ...
Cell & Microbiology
Sep 14, 2020
0
111
Many viruses, including HIV and influenza A, mutate so quickly that identifying effective vaccines or treatments is like trying to hit a moving target. A better understanding of viral propagation and evolution in single cells ...
Biochemistry
Aug 20, 2020
0
175
Science is suffering from a replication crisis. Too many landmark studies can't be repeated in independent labs, a process crucial to separating flukes and errors from solid results. The consequences are hard to overstate: ...
Other
Aug 19, 2020
5
53
In an unexpected new finding, biochemists at the University of Massachusetts Amherst report observing that a damage-containment system in stressed bacteria can become overrun and blocked, but that this leads to cells responding ...
Cell & Microbiology
Aug 06, 2020
0
75
A protein that is critical for retrovirus replication may select viral genetic material for packaging within the nuclei of host cells, rather than in the cytoplasm, as was previously believed. The research, led by a team ...
Cell & Microbiology
Jul 30, 2020
0
70
The cytosolic iron sulfur assembly (CIA) pathway is required for the insertion of Fe-S clusters into proteins, including many DNA replication and repair factors. Despite its essential cellular function, this pathway remains ...
Molecular & Computational biology
Jul 06, 2020
0
4
Epigenetic regulation of gene expression is associated with switching between chromatin states characterized by distinct histone modifications.
Cell & Microbiology
Jun 30, 2020
0
119
