Novel DNA repair mechanism preserves genome integrity
As David Cortez, Ph.D., tells the story of his research team's latest discovery, he shakes his head in disbelief.
Mar 01, 2019
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Researchers discover cell mechanism that delays and repairs DNA damage that can lead to cancer
Researchers from the University of Copenhagen have identified a specific mechanism that protects cells from natural DNA errors that could permanently damage the genetic code and lead to diseases such as cancer. The study ...
Researchers identify how the bacterial replicative helicase opens to start DNA replication process
DNA replication is a complex process in which a helicase ring separates the DNA molecule's two entwined and encoded strands, allowing each to precisely reproduce its missing half. Until recently, however, researchers have ...
Scientists lay foundation for single-cell level understanding of DNA replication
A research team has established a novel method to scrutinize DNA replication in individual cells. This method allowed them to obtain a detailed genome-wide view of replicated and unreplicated sequence distribution in each ...
Scientists poised to study reproducibility of Brazilian biomedical research
A project to assess the reproducibility of biomedical research in Brazil has been described today in the open-access journal eLife.
Yeast study prompts rethink of DNA safekeeping
DNA replication is more prone to errors at times of stress leading to mutations that could cause disease.
Frog eggs help researchers understand repair of DNA damages
The DNA replication process in which cells divide to create new cells also triggers repair of DNA damage, researchers from the University of Copenhagen report in a new study. The researchers studied extracts from frog eggs, ...
How do carrier proteins transport ADP and ATP in and out of mitochondria?
Scientists at the MRC-MBU in Cambridge, U.K., have discovered how a key transport protein, called the mitochondrial ADP/ATP carrier, transports adenosine triphosphate (ATP), the chemical fuel of the cell. This process is ...
Researchers unravel mystery of how, when DNA replicates
A team of Florida State University researchers has unlocked a decades-old mystery about how a critical cellular process is regulated and what that could mean for the future study of genetics.
Without Dna2, genes can jump into DNA breaks
Cells have in place a number of mechanisms to protect the integrity of the genome, including processes that repair mistakes that may occur during DNA replication. The enzyme Dna2 participates in DNA repair, but little is ...
